NEEDS DELETED - Functional Assessment in Liver Transplant Candidates (FrAILT) Study

Primary Investigator
M
Marwan Ghabril

Primary Investigator

Administratively Closed
18 years - 100 years
All
Phase N/A
10 participants needed
1 Location

Brief description of study

What is this study about?
This will be a prospective cohort study of patients with liver disease. The researchers want to gather information through a series of various tests that can be used in the future to guide diagnosis and treatment of cognitive impairment including Alzheimer’s and related dementias in individuals who have undergone liver transplantation.
 
THIS STUDY IS ENROLLING BY INVITATION ONLY

Detailed description of study

What will happen during the study?

Patients will be asked to perform the following study procedures:

  •     Assessment of cognitive function, quality of life, and/or personality using cognitive tests and questionnaires.
  •   Measures of frailty and disability selected to capture the multi-dimensional aspects of frailty including functional status and physiologic reserve:
  •   Fried Frailty Score: weakness (test of grip strength), exhaustion (patient interview), slowness (gait speed), low activity (patient interview) Short Physical Performance Battery: repeated chair stands, balance testing with feet together, 13-foot walk
  •   Laboratory tests will all be obtained from the medical record: creatinine, total bilirubin, INR, sodium, albumin. All of these tests are necessary for listing for liver transplantation.
  •   Blood draw, urine and stool samples will be collected for a sub-group of 1000 patients.
  •   Adipose, muscle, liver tissue, and blood will be collected during the liver transplant surgery for a sub-group of 1000 patients

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: End Stage Liver Disease
  • Age: 18 years - 100 years
  • Gender: All

Inclusion criteria
  • Are seen for the treatment of liver disease

Updated on 25 Aug 2026. Study ID: GI-UCSF-ADRD

Interested in the study?

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