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Found 736 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)

J
Jonathan L. Berkowitz, MD, PhD
18 years and older
All genders
Phase 2
Interventional
This study is designed to assess the safety and efficacy of lenvatinib in combination withbrolizumab versus standard of care (SOC) chemotherapy, and to also assess the safety andy of lenvatinib monotherapy in participants with recurrent/metastatic head and neckquamous cell carcinoma (R/M HNSCC) that have progressed after platinum therapy and agrammed …
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study (STOP360AG)

C
Cynthia Brown, MD
6 years and older
All genders
Phase 4
Interventional
The purpose of this study is to look at pulmonary exacerbations in people with cysticbrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms inwith CF that needs medical intervention. Both …
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Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age

J
James Chmiel
1-11 years
All genders
Phase 3
Interventional
The purpose of this study is to evaluate the pharmacokinetics, safety, tolerability andy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants with at1 triple combination responsive (TCR) mutation in the cystic fibrosis transmembraneductance regulator (CFTR) gene.
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A Study of JNJ-55308942 in the Treatment of Bipolar Depression

S
Susan Conroy, MD
18-64 years
All genders
Phase 2
Interventional
The purpose of this study is to evaluate the efficacy of JNJ-55308942 compared to placebo onymptoms of depression in participants with bipolar disorder (BD) in a major depressivede (MDE) at Week 6.
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Cast or Operation for Medial Epicondyle Fracture Treatment in Children (COMET)

E
Erika Daley
7-17 years
All genders
Interventional
This protocol describes a multicenter, prospective randomized superiority trial of medialdyle fracture treatments comparing functional outcomes between children treated withve reduction and fixation or non-operative immobilization.
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Distal Radius Interventions for Fracture Treatment (DRIFT)

E
Erika Daley
4-10 years
All genders
Interventional
This protocol describes a multicenter, prospective randomized superiority trial comparingunctional outcomes between children treated with sedated reduction versus no formalduction.
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Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section (PPAP C-Section)

D
David Haas, MD
18 years and older
Healthy Volunteer
Female
The purpose of this collaborative CTSA (Clinical and Translational Science Award) applicationdevelop an innovative perioperative precision analgesia platform (PPAP) to improvegesia and reduce serious immediate and long-term adverse outcomes of perioperativeds in breastfeeding mothers and their infants
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TheraSphere With Durvalumab and Tremelimumab for HCC (ROWAN)

P
Paul Haste
18 years and older
All genders
Phase 2
Interventional
The objective of the ROWAN clinical study is to assess the efficacy of local tumor control in HCC patients who receive TheraSphere followed by durvalumab and tremelimumab.
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Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen

K
Kate Hawa
2-21 years
Healthy Volunteer
All genders
Phase 4
This study will evaluate changes in the fecal microbiome in constipated pediatric patients before and after antegrade continence enema placement and initiation of antegrade enemaushes. Subjects will have their microbiome sequenced prior to placement by obtaining a. Pre-antegrade continence enema placement results will be compared to fecalbtained at 0, 4, …
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(HALT) Embrace Hydrogel Embolic System (HES) Study of Embolization in Peripheral Arterial Bleeds

M
Matthew S. Johnson, MD
18 years and older
All genders
Interventional
To evaluate the safety and effectiveness of Embrace Hydrogel Embolic System for theheter embolization of peripheral arterial bleeds.
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