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Found 10 jodi-skiles trials

A listing of jodi-skiles medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

PROJECT SICKLE CURE

J
Jodi Skiles
Healthy Volunteer
All genders
We want to learn more about the long-term effects of Hematopoietic Stem Cell Transplantation (HSCT) on the brain and blood vessels of patients with sickle cell disease. We want to understand: how the brain looks on scans, how it functions and what brain complications develop with BMT for sickle cell …
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Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

J
Jodi Skiles
All genders
Observational
The primary purpose of the Research Sample Repository is to make blood samples available forh studies related to histocompatibility and hematopoietic cell transplantation (HCT)her cellular therapy. Representatives of participating centers and investigators or research groups may requesth samples contained in the Research Sample Repository for the purpose ofducting research including: …
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Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation

J
Jodi Skiles
2-13 years
All genders
Phase 2
Interventional
This study aims to enroll 58 pre-adolescent (<13 years) pediatric participants with sickledisease (SCD) who have a pre-adolescent sibling bone marrow donor. All participants will go through a pre-transplant evaluation to find out if there are health problems that will keep them from being able to receive the transplant. It …
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A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD22 for Relapsed/Refractory Leukemia or Lymphoma

J
Jodi Skiles
All genders
Phase 1/2
Interventional
Patients with relapsed or refractory leukemia or lymphoma are often refractory to furtherhemotherapy. In this study, the investigators will attempt to use T cells obtained directlyhe patient, which can be genetically engineered to express a chimeric antigen receptor (CAR). The CAR used in this study can recognize CD22, a protein …
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Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients with Symptomatic Sickle Cell Disease

J
Jodi Skiles
5-45 years
All genders
We're doing this study to learn if a haploidentical transplant is safe and effective to treat SCD.
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A study of Hematopoietic Stem Cell Transplantation (HSCT) in Non-Malignant Disease using a Reduced-Intensity preparatory regime with Campath-1H Fludarabine and Melphalan

J
Jodi Skiles
1-21 years
All genders
The overall purpose of this research is to treat diseases that are not cancer but are improved by bone marrow transplantation.
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A Phase 1/2 Multi-Center Trial of Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

A
April Rahrig, MD
3-30 years
All genders
Phase 1/2
Interventional
To determine the recommended phase 2 dose (RP2D) of vorinostat in children, adolescents and young adults following allogeneic HCT. Eligibility:A prospective patient for allogeneic BMT for malignant hematologic conditions Ages 3-30 Diagnoses include:Acute Leukemia in remissionChronic Myeologenous Leukemia (CML)  Myelodysplastic syndrome (MDS) Additonal criteria must be met based on determination …
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Biomarkers of endothelial dysfunction in pediatric patients receiving high intensity chemotherapy/irradiation

J
Jodi Skiles
All genders
The purpose of this study is to collect blood specimens and data from patients undergoing stem cell transplant.
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Managed Access Program (MAP) to Provide Access to CTL019, for ALL or DLBCL Patients With Out of Specification Leukapheresis Product and/or Manufactured Tisagenlecleucel Out of Specification for Commercial Release

J
Jodi Skiles
All genders
The purpose of this Managed Access Program (MAP) Treatment Plan is to provide access to CTL019, for acute lymphoblastic leukemia (ALL) or diffuse large b-cell lymphoma (DLBCL) patients with out of specification leukapheresis product and/or manufactured tisagenlecleucel out of specification for commercial release where no overwhelming safety concerns has been …
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A Phase II Pilot Trial to Estimate Survival After a Non-total Body Irradiation (TBI) Based Conditioning Regimen in Patients Diagnosed With B-acute Lymphoblastic Leukemia (ALL) Who Are Pre-allogeneic Hematopoietic Cell Transplantation (HCT) Next-generation-sequence (NGS) Minimal Residual Disease (MRD) Negative

J
Jodi Skiles
1-25 years
All genders
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT).
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