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Found 10 roman-natoli-md trials

A listing of roman-natoli-md medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Long-FRI

R
Roman Natoli, MD
18-85 years
All genders
The overall aim of this proposal is to identify a biomarker diagnostic strategy that can be implemented in patients sustaining fractures at high-risk for infection. This proposal will address the hypothesis that there is a biomarker signature that will be able to discriminate between patients who develop FRI compared to …
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What is the role of Next Generation Sequencing (NGS) in nonunion of orthopaedic cases?

R
Roman Natoli, MD
18-100 years
All genders
The purpose of this study is to investigate the role of Next Generation Sequencing (NGS), a molecular method to detect bacterial DNA presence, in 1) diagnosis of infected nonunion compared to microbiological culture and 2) compare NGS signal with clinical outcome and fracture healing.
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Utility of Serum Biomarkers in Diagnosing Fracture-Related Infections: A Pilot Study

R
Roman Natoli, MD
18-85 years
Healthy Volunteer
All genders
The primary aim will be to determine if serum inflammatory biomarkers can reliably diagnose FRIs as compared to a standardized definition of FRI.
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PREVENTion of Clot in Orthopaedic Trauma (PREVENT CLOT): A Randomized Pragmatic Trial Comparing the Complications and Safety of Blood Clot Prevention Medicines Used in Orthopaedic Trauma Patients

R
Roman Natoli, MD
All genders
The purpose of this study is to help determine the best treatment for preventing blood clots that are formed following trauma that could potentially lead to death.
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Virtual Mechanical Testing of Humeral Fracture Healing and Nonunion

R
Roman Natoli, MD
18-70 years
All genders
This study will examine whether the stiffness of a partially healed bone, measured using a 3D image and computer simulation constructed from a CT scan can predict at a very early stage if there are problems with how the bone is healing. 
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Serum Protein-Based Indices for the Progression of Fracture Healing and Nonunion

R
Roman Natoli, MD
18-70 years
All genders
To define a serum protein-based diagnostic for the progression and failure of fracture healing, through the identification of a set of serum proteins that appear at early times of biological healing and show a specific correlation with later radiological and functional signs used to define delayed healing and non-union. 
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Early Serial Sampling of Peripheral Blood for the Purposes of Predicting Fracture Nonunion

R
Roman Natoli, MD
18-60 years
All genders
The purpose of this study is to determine if certain molecules in the bloodstream can be used to improve our ability to predict the development of a nonunion or unhealed bone or fracture related infection.  This study is looking at many molecules and we will determine if the levels of …
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COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study (COPEiOS)

R
Roman Natoli, MD
60-100 years
All genders
Interventional
The COgnitive and Physical Exercise to improve Outcomes after Surgery (COPE-iOS) study isg the hypothesis that a pragmatic program combining computerized cognitive training andhysical training throughout the perioperative period will improve long-term cognitive and disability outcomes in older surgical patients at high risk for decline. To accomplish these goals, the …
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Fracture-Related Outcome Study for Operatively Treated Tibia Shaft Fractures (FROST)

R
Roman Natoli, MD
18-100 years
All genders
Observational
Approximately 1000 patients presenting with tibial shaft fractures (AO type 42) will bed prospectively in this registry. All patients are treated and followed at 6 weeks, 6hs and 1 year postoperative always following the local standard of care (routine) visithedule up to 36 months if required. Data collection includes patient …
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Effect of Early Weight Bearing on Rehabilitation Outcomes in Patients with Traumatic Ankle and Tibial Plateau Fractures

R
Roman Natoli, MD
18-65 years
All genders
The purpose of this study is to compare the usual practice of bearing weight (“delayed weight bearing”) with weight bearing sooner in the healing process. We will use study data to determine if early weight bearing improves recovery after injury.
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