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Found 10 bryan-xin trials

A listing of bryan-xin medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With The Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)

B
Bryan Schneider, MD
18 - 100
All genders
Phase 3
Interventional
What is the purpose of this study?This Phase III, randomized, open-label, multicenter study will evaluate the efficacy andy of giredestrant plus everolimus compared with the physician's choice of endocrineherapy plus everolimus in participants with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer …
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A Single Arm Phase II Study of ADjuvant Endocrine Therapy, Pertuzumab, and Trastuzumab for Patients With Anatomic Stage I Hormone Receptor-positive, HER2-positive Breast Cancer (ADEPT)

T
Tarah Ballinger, MD
18 or above
All genders
Phase 2
Interventional
What is the purpose of this study?This research study is studying a combination of HER2-directed therapies (trastuzumab anduzumab) and hormonal therapy as a treatment after surgery for hormone receptor positive breast cancer. The study drugs involved in this study are: A combination of trastuzumab and pertuzumab given as an injection …
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Phase II Trial of Carboplatin +/- Tocilizumab for Metastatic Triple Negative and ER-low Breast Cancers

K
Kathy Miller, MD
18 or above
All genders
Phase 2
Interventional
What is the purpose of this study?This is a randomized Phase II study of carboplatin monotherapy vs. carboplatin combined with tocilizumab in in Black and non-Black patients with metastatic triple negative or ER low breast cancer. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients …
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SHORTER ANTHRACYCLINE-FREE CHEMO IMMUNOTHERAPY ADAPTED TOPATHOLOGICAL RESPONSE IN EARLY TRIPLE NEGATIVE BREAST CANCER (SCARLET), ARANDOMIZED PHASE III STUDY

K
Kathy Miller, MD
16 - 100
All genders
Phase 3
What is this study about?This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill …
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A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET)

T
Tarah Ballinger, MD
18 - 60
Female
Phase 3
What is this study about?This study will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with estrogen receptor (ER)-positive, HER2-negative tumors and …
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Evaluating Disparities in Precision Oncology: An Observational Trial in the context of a Real-World Academic Practice Model (EDPO)

B
Bryan Schneider, MD
18 or above
All genders
Observational
What is the purpose of this study?This is a non-randomized observational trial designed to collect detailed clinical, social determinant, and genomic data from patients enrolled in molecular oncology tumor boards across four comprehensive cancer centers.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not …
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Phase 1 Imaging Study of 68Ga-R10602 in Hormone Receptor-Positive Breast Cancer

K
Kathy Miller, MD
18 - 100
All genders
Phase 1
What is the purpose of this study?This trial studies how well 68-Ga RM2 works with PET/MRI in imaging patients with estrogen receptor-positive breast cancer. 68-Ga-RM2 is an agent used in diagnostic imaging.Primary: To describe the safety of 68Ga-R10602.Secondary - To describe the biodistribution of 68Ga-R10602 in Study Participants with hormone …
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Phase Ib Active Immunotherapy Trial (Expansion) with a Combination of Two Chimeric (Trastuzumab-like and Pertuzumab-like) HER-2 B Cell Peptide Vaccine emulsified in ISA 720 Adjuvant in Patients with Advanced Solid Tumors

K
Kathy Miller, MD
18 - 100
All genders
Phase 1/2
What is the purpose of this study?This phase I trial studies the side effects and best dose of vaccine therapy in treating patients with metastatic solid tumors. Vaccines made from antibodies and peptides combined with tumor cells may help the body build an effective immune response to kill tumor cells.THIS …
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Phase I/II Study of Stereotactic Radiosurgery with Concurrent Administration of DNA DamageResponse (DDR) Inhibitor (OLAparib) Followed by Adjuvant Combination of DuRvalumab(MEDI4736) and Physicians Choice Systemic Therapy in Subjects with BreAst Cancer Brain Metastases (SOLARA)

K
Kathy Miller, MD
18 - 100
All genders
Phase 1/2
What is the purpose of this study?This study is a Phase I/II study evaluating the safety and effectiveness of focused radiation therapy (radiosurgery) together with olaparib, followed by immunotherapy, for patients with brain metastases from triple negative or BRCA-mutated breast cancers.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with …
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Targeted Prevention of Postpartum-Related Breast Cancer

T
Tarah Ballinger, MD
18 - 45
Female
Phase 2
What is the purpose of this study?This phase II trial tests whether low-dose aspirin can affect markers of inflammation in postpartum (after childbirth) patients with benign breast disease planning to have a breast biopsy. Chronic inflammation may increase the risk of postpartum related breast cancer. Low-dose aspirin is a non-steroidal …
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