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Found 11 peyton-bohle trials

A listing of peyton-bohle medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study) (ACTION)

M
Michael Ferguson, MD
All genders
Phase 3
Interventional
What is the purpose of this study?This is a randomized, double-blind, placebo-controlled, parallel-group, international, Phase 3 study in patients with newly diagnosed H3 K27M-mutant diffuse glioma to assess whether treatment with ONC201 following frontline radiotherapy will extend overall survival and progression-free survival in this population. Eligible participants will have histologically …
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A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

J
Jenny Belsky, DO
5-60 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients with stage I and II classical Hodgkin lymphoma. Brentuximab vedotin is in …
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Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma

J
Jenny Belsky, DO
2 years and older
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares the effects of nivolumab with chemo-immunotherapy versushemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with …
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A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)

S
Sandeep Batra, MD
2-21 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600Eutation and is not …
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OSTEOPATHIC MEDICINE SUPPORTIVE CARE IN PEDIATRIC

J
Jenny Belsky, DO
2-30 years
All genders
What is the purpose of this study?The purpose of this study is to find compare therapy side effects with a treatment called osteopathic manipulative treatment to standard of care medicines without osteopathic manipulative treatment. Osteopathic medicine is a distinct form of medical practice that offers the added benefit of hands-on …
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Key Adverse Events Following Childhood Cancer

S
Sandeep Batra, MD
21 years and younger
All genders
What is the purpose of this study?This clinical trial studies cancer survivors to identify those who are at increased risk of developing late-occurring complications after undergoing treatment for childhood cancer. A patient's genes may affect the risk of developing complications, such as congestive heart failure, avascular necrosis, stroke, and second …
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The Project: Every Child Protocol: A Registry Eligibility Screening Biology and Outcome Study

S
Sandeep Batra, MD
1-25 years
All genders
What is the purpose of this study?This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent …
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Pilot Pharmacokinetic Study of VAL-413 (Orotecan) in Patients with Recurrent Pediatric Solid Tumors

K
Kyle William Jackson
1-30 years
All genders
Phase 2
What is the purpose of this study?To establish the recommended phase II dose of a flavored preparation of orally administered irinotecan (VAL-413) when given in combination with temozolomide for five consecutive days. To characterize and compare the pharmacokinetic profiles of VAL-413 and conventional irinotecan given orally To evaluate the palatability …
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AGCT1531: A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors

S
Sandeep Batra, MD
49 years and younger
All genders
Phase 3
What is the purpose of this study?This phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. …
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A Randomized Web-based Physical Activity Intervention among Children and Adolescents with Acute Lymphoblastic Leukemia

S
Sandeep Batra, MD
8-15 years
All genders
What is the purpose of this study?This randomized clinical trial studies how well web-based physical activity intervention works in improving long term health in children and adolescents with newly diagnosed acute lymphoblastic leukemia that shows a decrease in or disappearance of signs and symptoms. Regular physical activity after receiving treatment …
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