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Found 12 kevin-bell trials

A listing of kevin-bell medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study) (ACTION)

M
Michael Ferguson, MD
All genders
Phase 3
Interventional
What is the purpose of this study?This is a randomized, double-blind, placebo-controlled, parallel-group, international, Phase 3 study in patients with newly diagnosed H3 K27M-mutant diffuse glioma to assess whether treatment with ONC201 following frontline radiotherapy will extend overall survival and progression-free survival in this population. Eligible participants will have histologically …
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DAY101 vs. Standard of Care Chemotherapy in Pediatric Patients With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

M
Michael Ferguson, MD
25 or below
All genders
Phase 3
Interventional
What is the purpose of this study?This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus standard of care (SoC) chemotherapy in patients with pediatric low-grade glioma (LGG) harboring an activating rapidly accelerated fibrosarcoma (RAF) alteration requiring front-line …
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Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

S
Scott Coven
1 - 25
All genders
Phase 1
Interventional
What is the purpose of this study?This phase I trial studies the side effects and best dose of trametinib and everolimus ing pediatric and young adult patients with gliomas that have come back (recurrent). Trametinib acts by targeting a protein in cells called MEK and disrupting tumor growth.verolimus is a …
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The Rare Brain Tumour Consortium Registry and Biobank

S
Scott Coven
18 or below
All genders
What is the purpose of this study?The Biobank being created by this study is located at the Hospital for Sick Children in Toronto, Canada and is a research registry that collects biological samples and medical information from individuals in participating centers around the world. The purpose of this registry is …
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The Project: Every Child Protocol: A Registry Eligibility Screening Biology and Outcome Study

S
Sandeep Batra, MD
1 - 25
All genders
What is the purpose of this study?This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent …
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A Randomized, Open-Label, Phase 2 Study Evaluating Abemaciclib inCombination With Temozolomide Compared to Temozolomide Monotherapy in Children and Young Adults With Newly Diagnosed High-Grade Glioma Following Radiotherapy

S
Scott Coven
20 or below
All genders
Phase 2
What is the purpose of this study?The purpose of this study is to measure the benefit of adding abemaciclib to the chemotherapy, temozolomide, for newly diagnosed high-grade glioma following radiotherapy.Your participation could last approximately 11 months and possibly longer depending upon how you and your tumor respond.The purpose of this …
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A Phase 3 Randomized Study of Selumetinib Versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG).

S
Sandeep Batra, MD
2 - 21
All genders
Phase 3
What is the purpose of this study?This phase III trial studies if selumetinib works just as well as the standard treatment with carboplatin/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if selumetinib is better than CV in improving vision in subjects with LGG of the …
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A Phase 3 Randomized, Placebo-Controlled Trial Evaluating Memantine (IND# 149832) for Neurocognitive Protection in Children Undergoing Cranial Radiotherapy as Part of Treatment for Primary Central Nervous System Tumors

S
Sandeep Batra, MD
4 - 17
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares memantine to usual treatment in treating patients with primary central nervous system tumors. Memantine may block receptors (parts of nerve cells) in the brain known to contribute to a decline in cognitive function. Giving memantine may make a difference …
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A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

S
Sandeep Batra, MD
12 - 21
All genders
Phase 1/2
Interventional
What is the purpose of this study?This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called …
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A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma

S
Sandeep Batra, MD
2 - 25
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial investigates the best dose of vinblastine in combination withumetinib and the benefit of adding vinblastine to selumetinib compared to selumetinibg children and young adults with low-grade glioma (a common type of brain) that has come back after prior treatment (recurrent) …
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