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Found 11 kevin-bell trials

A listing of kevin-bell medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Michael Ferguson, MD
All genders
Phase 3
Interventional
What is the purpose of this study?This is a randomized, double-blind, placebo-controlled, parallel-group, international, Phase 3 study in patients with newly diagnosed H3 K27M-mutant diffuse glioma to assess whether treatment with ONC201 following frontline radiotherapy will extend overall survival and progression-free survival in this population. Eligible participants will have histologically …
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M
Michael Ferguson, MD
25 years and younger
All genders
Phase 3
Interventional
What is the purpose of this study?This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus standard of care (SoC) chemotherapy in patients with pediatric low-grade glioma (LGG) harboring an activating rapidly accelerated fibrosarcoma (RAF) alteration requiring front-line …
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S
Sandeep Batra, MD
4-17 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares memantine to usual treatment in treating patients with primary central nervous system tumors. Memantine may block receptors (parts of nerve cells) in the brain known to contribute to a decline in cognitive function. Giving memantine may make a difference …
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S
Sandeep Batra, MD
2-25 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial investigates the best dose of vinblastine in combination withumetinib and the benefit of adding vinblastine to selumetinib compared to selumetinibg children and young adults with low-grade glioma (a common type of brain) that has come back after prior treatment (recurrent) …
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Sandeep Batra, MD
12-21 years
All genders
Phase 1/2
Interventional
What is the purpose of this study?This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called …
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S
Scott Coven
1-25 years
All genders
Phase 1
Interventional
What is the purpose of this study?This phase I trial studies the side effects and best dose of trametinib and everolimus ing pediatric and young adult patients with gliomas that have come back (recurrent). Trametinib acts by targeting a protein in cells called MEK and disrupting tumor growth.verolimus is a …
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S
Sandeep Batra, MD
2-21 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600Eutation and is not …
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S
Sandeep Batra, MD
3-30 years
All genders
Phase 2
Interventional
What is the purpose of this study?This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients withgerminomatous germ cell tumors (NGGCT) that have not spread to other parts of the brainbody (localized). This study has …
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S
Scott Coven
18 years and younger
All genders
What is the purpose of this study?The Biobank being created by this study is located at the Hospital for Sick Children in Toronto, Canada and is a research registry that collects biological samples and medical information from individuals in participating centers around the world. The purpose of this registry is …
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Sandeep Batra, MD
1-25 years
All genders
What is the purpose of this study?This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent …
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