A listing of site-public-contact medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
This study investigates the effects of adding an investigational medication to a standard treatment for patients with high-risk renal cell carcinoma (RCC). RCC is a type of kidney cancer. The purpose of this study is to see if the investigational medication, when combined with the standard treatment, works better than …
What is the purpose of this study?This phase II Expanded Lung-MAP treatment trial tests how well amivantamab-subcutaneous (SC) works in treating patients patients with MET amplification non-small cell lung cancer. Amivantamab-SC is a drug that reduces extra copies of the MET gene, a change present in your tumor. Giving amivantamab-SC …
What is the purpose of this study?This phase II trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with undifferentiated pleomorphic sarcoma (UPS) or a related poorly differentiated sarcoma that has spread from where it first started to other places in the …
What is the purpose of this study?This is a multicenter, first-in-human (FIH), open label, Phase 1 dose escalation and recommended Phase 2 dose (RP2D) extension trial with a primary objective to define the RP2D of SRG-514 when administered intraoperatively to patients undergoing breast-conserving cancer surgery. SRG-514 will be investigated utilizing …
What is the purpose of this study?Primary Objectives1. To determine the safety and toxicity profile of a chimeric HER2 B-cell peptide vaccine in patients with high-risk HER2 positive breast cancer after completion of standard curative therapy and adjuvant HER2-directed antibody therapy2. To determine immune responses induced by a chimeric HER2 …
This study investigates an investigational gene therapy for adults with advanced or metastatic solid tumors. The purpose is to activate the immune system to fight cancer using a gene therapy vector, which is a non-replicating product designed to target cancer cells. The gene therapy includes a suicide gene that, with …
What is the purpose of this study?The purpose of this study is to find out if adding two drugs called quemliclustat and zimberelimab to the usual chemotherapy drugs can increase the amount of time a person lives with biliary tract cancer without it getting worse. Researchers also want to study …
What is the purpose of this study?The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory …
What is the purpose of this study?Primary 1. To assess the safety and tolerability of the combination of CLBR001 + ABBV-461 in subjects with locally advanced or metastatic breast cancer. 2. To identify an Optimal Biologic Dose (OBD) and/or a Maximum Tolerated Dose (MTD) of CLBR001 and ABBV-461. Secondary 1. …
This study investigates the use of an investigational medication in adults with advanced solid tumors or non-Hodgkin lymphoma (NHL). The purpose is to learn about the safety and effects of different doses and ways of giving the medication. Solid tumors are abnormal masses of tissue that can be cancerous, and …
