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Found 61 results for site-public-contact
A listing of site-public-contact medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Abatacept in Immune Checkpoint Inhibitor Myocarditis (ATRIUM)
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Suparna C. Clasen, MD, MSCE
The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden …
Using a Novel Lay Patient Navigation Model to Improve Cascade Testing Rates for Hereditary Cancer Syndromes in Black Patients and Their Family Members
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Nawal Kassem
The purpose of this study is to improve genetic testing rates in families of Black patients who are found to have a hereditary cancer syndrome. Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: …
Pre-Rehabilitation for Female Patients Undergoing Pelvic Radiotherapy
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Namita Agrawal
The purpose of this study is to examine the feasibility of adding pre-rehabilitation pelvic health physical therapy to standard of care radiation therapy treatment plan for female patients who have been diagnosed with cervical, vaginal, vulvar, uterine, or anal cancer and are a candidate for curative pelvic radiation with external …
Circulating Tumor HPV DNA Driven Adjuvant Treatment Deintensification after Transoral Surgery for HPV-Positive Squamous Cell Carcinoma of the Oropharynx
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Michael W. Sim, MD
People with Oropharyngeal squamous cell carcinoma (OPSCC) typically receive standard treatment with a combination of chemotherapy, radiation therapy, and surgery. Due to the intensity of standard treatment, survivors may experience unwanted long-term side effects. The goal of this research study is to see if de-intensifying treatment still provides the same, …
NearWave optical molecular monitoring for predicting complete pathological response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients
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Tarah Ballinger, MD
The purpose of this study is to assess the feasibility of the NearWave optical molecular monitoring system for monitoring therapy progression and predicting pathologic complete response (pCR) of breast cancer patients undergoing neoadjuvant chemotherapy (NAC). Interested in participating? For more information about this research study or other cancer-related clinical trials at …
A Randomized Phase II Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas
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Samantha Armstrong
What is the purpose of this study?This phase II trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with undifferentiated pleomorphic sarcoma (UPS) or a related poorly differentiated sarcoma that has spread from where it first started to other places in the …
Prospective Study on Radiation Induced Cardiotoxicity Assessed By PET-CT for Locally Advanced Non-Small Cell Lung Cancer
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Tim Lautenschlaeger
There has been evidence that patients being treated with chemoradiation for Non-Small Cell Lung Cancer (NSCLC) have experienced cardiac toxicities (heart damage). This study is exploring if testing patients hearts that have been diagnosed with NSCLC before and after treatment can help investigators decrease heart damage for patients in the …
A Phase II Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiationfor the Treatment of Early-Stage Anal Cancer
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Anita Turk, MD
Primary Objective:1. To determine the clinical complete response rate (cCR) assessed following weekly carboplatin and paclitaxel in combination with pembrolizumab and radiation for the treatment of early-stage anal cancer. Secondary Objectives:1. To assess the safety and tolerability of weekly carboplatin and paclitaxel in combination with pembrolizumab and radiation for the treatment …
A Phase 1, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Investigate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of the PTK7-Targeted Antibody-drug Conjugate DAY301 in Patients with Locally Advanced or Metastatic Solid Tumors
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Greg Durm, MD
This is a Phase 1a/1b, open-label, dose escalation and expansion study to evaluate the safety and anti-tumor activity of DAY301, a PTK7-directed antibody-drug conjugate in patients with advanced or metastatic solid tumors. Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive …
A Phase 3, Open-label, Multicenter, Randomized Trial of TrastuzumabDeruxtecan with Bevacizumab Versus Bevacizumab Monotherapy asFirst-line Maintenance Therapy in HER2-Expressing Ovarian Cancer.
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Jessica Parker
This clinical trial is designed to evaluate the efficacy and safety of T-DXd in combination with bevacizumab versus bevacizumab monotherapy as first-line maintenance therapy, in participants with human epidermal growth factor 2 (HER2)-expressing (immunohistochemistry [IHC] 3+/2+/1+) advanced high-grade epithelial ovarian cancer.Interested in participating? For more information about this research study …
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