Traction Neurectomy, Regenerative Peripheral Nerve Interfaces, and Targeted Muscle Reinnervation for Proximal Digital Amputations: A Prospective, Randomized Controlled Trial
J
Joshua Adkinson, MD
Primary Investigator
Not Recruiting
18 years - 100 years
All
Phase
N/A
36 participants needed
2 Locations
Brief description of study
One of the main side effects of amputation is nerve pain. This happens because the nerves that go to the amputated part are cut but are still receiving signals from the brain. The purpose of this study is to figure out if there is a method of amputation that can help prevent this nerve pain from occurring.
Detailed description of study
Participants will complete a grip strength test and questionnaire before being randomly assigned to one of three groups, determining the method of surgery for their finger amputation. Traction neurectomy (TN) means that the nerves will be cut under tension, like pulling out a rubber band and then cutting it with scissors; targeted muscle reinnervation (TMR) means that after the nerves are cut, they’re moved to other muscles; regenerative peripheral nerve interfaces (RPNI) means that after the nerves are cut, a tiny piece of muscle from the area near the nerve is wrapped around the end of the nerve.
After surgery, participants will have the same follow-up appointments that they would have even if they were not participating in the study. At the three and six month follow-up, they will repeat the survey and grip strength test as well as rate their pain level.
Researchers will collect information from participant medical records, such as physical exam results and medical history related to their finger.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Amputation, Nerve Pain
-
Age: 18 years - 100 years
-
Gender: All
Individuals at least 18 years of age requiring single finger amputation at the level of the proximal interphalangeal joint or more proximal.
Updated on
01 Aug 2024.
Study ID: 1907889836
