A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens
Kamnesh Pradhan, MD
Primary Investigator
Brief description of study
This research study is collecting and storing samples of bone marrow and blood from patients with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and help predict the recurrence of cancer.
Detailed description of study
The purpose of this study is to establish a mechanism to bank specimens of tumor cells and host germline DNA from patients with acute lymphoblastic leukemia (ALL) at first and subsequent relapse; and to make these specimens available to qualified researchers to study the biology of ALL.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: acute lymphoblastic leukemia
-
Age: 30 years or below
-
Gender: All
Inclusion Criteria
Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin lymphoma
In first or subsequent marrow relapse with ? 25% blasts in bone marrow and/or peripheral blood
Bone marrow and/or peripheral blood samples (? 5 mL) required at the time of diagnosis of relapse
No concurrent systemic antileukemic treatment administered for current relapse
Intrathecal chemotherapy allowed
On-therapy relapse allowed
