PrecISE: Precision Interventions for Severe and/or Exacerbation-Prone Asthma
J
James Chmiel
Primary Investigator
Administratively Closed
12 years - 80 years
All
Phase
2
2 Locations
Brief description of study
PrecISE is a multi-site study, sponsored by the National Heart, Lung, and Blood Institute. We are inviting people to participate in PrecISE who: 1) are age 12 or older, 2) meet guideline criteria for severe asthma, 3) currently have uncontrolled asthma, or continue to have exacerbations (attacks), and 4) are on a stable regimen of asthma medications (controller/daily medication). We will find out if you qualify for the study after you finish the screening tests.
Detailed description of study
This study is designed to investigate new treatments for asthma that are thought to work better in some patients than in others. The data from this research study will be used to determine which treatments work and what kind of patient benefits the most from that treatment.
If you choose to take part in the study, you can receive several different treatments depending on when you begin the study. You will take each treatment for about 4 months, and then take a break for 2 to 4 months, before starting another treatment. The study will run for about 3 ½ years, and most of the people participating in the study will go through 2-3 different treatments before finishing the study.
If you choose to take part in the study, you can receive several different treatments depending on when you begin the study. You will take each treatment for about 4 months, and then take a break for 2 to 4 months, before starting another treatment. The study will run for about 3 ½ years, and most of the people participating in the study will go through 2-3 different treatments before finishing the study.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: asthma
-
Age: 12 years - 80 years
-
Gender: All
You may be eligible to join if you:
• Are age 12 and up.
• Have severe asthma as defined by commonly accepted guidelines.
• Currently have uncontrolled asthma, or worsening asthma & attacks.
• Are on a stable regimen of asthma medications.
• Are not pregnant and not breastfeeding.
• Are not taking part in other clinical trials.
• Have access to a smartphone or tablet for use during the study.
Additional Information:
Get in touch with a coordinator:
PrecISE is a network of leading universities, medical doctors, and scientists dedicated to helping people living with severe asthma. The two goals of PrecISE are to (1) evaluate exciting new treatments for severe asthma and (2) find patient subgroups for which these treatments work the best.
The main study website is: https://preciseasthma.org
Indiana Site Information:
PI: James F. Chmiel, MD
Research Team: Mary Heskett
Email: myasthma@iupui.edu
Phone: (317) 278-7119
Updated on
20 Mar 2025.
Study ID: 1909045607, PPUL-NIH-PRECISE
