Inclusion Criteria
For JIA, must have disease onset prior to age 16, and at least one of the following four criteria:
All systemic JIA (regardless of diagnosis date and joint count)
All JIA who have ever had active arthritis of 5 or more unique joints cumulatively since disease onset
Any JIA patient (regardless of diagnosis date and joint count) starting or re-starting methotrexate or any biologic agent, regardless of medication history (must be enrolled at the visit the medication is prescribed, or the immediate subsequent visit)
New onset JIA regardless of joint count and ILAR category (new onset is defined as diagnosed within the last six months)
For SLE, must have disease onset prior to age 18, and has been diagnosed within the past 24 months, or have a prior SLE diagnosis with new onset lupus nephritis within the past 24 months. Must meet at least four of the following clinical criteria and one immunologic criterion, or have a biopsy proving nephritis compatible with SLE:
Acute cutaneous lupus
Chronic cutaneous lupus
Oral ulcers
Nonscarring alopecia
Nonerosive arthritis
Serositis
Renal
Neurologic hemolytic anemia
Leukopenia
Thrombocytopenia
Also allowed are patients with the following related conditions, diagnosed within the past 24 months:
Acute cutaneous lupus (without SLE)
Chronic cutaneous lupus
Mixed connective tissue disease
Sjogren?s syndrome
Anti-phospholipid antibody syndrome
Probable SLE (at least 3 criteria in the last 24 months)
Exclusion Criteria
Greater than 21 years of age at the time of enrollment.