Parkinson's Progression Markers Initiative 2.0 Remote Study
T
Tatiana Foroud
Primary Investigator
Enrolling By Invitation
30 years - 100 years
All
Phase
N/A
100000 participants needed
1 Location
Brief description of study
What is the purpose of this study?
The purpose of PPMI 2.0 Remote is to find out if information collected remotely (by internet, mail, home visits, or phone applications) can help identify individuals at an increased risk of developing Parkinson’s Disease. Identifying at-risk individuals may also help researchers learn how to better develop and test new interventions intended to delay or prevent disease progression in the early stages of PD.
To accomplish this, the specific aims of the study are: a)Establish a comprehensive recruitment strategy targeting individuals likely to be at increased risk of PD. b)Develop a risk paradigm to determine criteria for study participants to be selected for dopamine transporter single photon emission computed tomography (SPECT) imaging c)Refine the risk paradigm based on accruing data collected in PPMI initiatives combined with imaging, clinical, and biomarker information collected in the PPMI Clinical study.
THIS STUDY IS ENROLLING BY INVITATION ONLY - Subjects will be identified through a number of mechanisms. Initially subjects are recruited through targeted outreach for increased risk for PD by the Michael J. Fox Foundation (sponsor) as well as PPMI clinical sites. These individuals are pushed to WRD (IRB 1703921430), where subjects will be identified as those who have completed genetic screening through the existing WRD study or reported other risk factors for PD, such as a family history of PD. These individuals will be invited to enroll in the PPMI Remote Data Collection study by WRD study staff or through website communication and/or email.
Detailed description of study
What will happen during the study?
- Participants will complete the University of Pennsylvania Smell Identification Test (UPSIT).
- This is a set of scratch and sniff, multiple choice questions to assess the ability to correctly identify odors.
- Participants will also enter information online about daily activities and may be asked to provide a saliva sample.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: all
-
Age: 30 years - 100 years
-
Gender: All
Inclusion criteria:
- Individuals at least 60 years of age, or at least 30 years of age with SNCA or rare genetic mutations.
- Increased risk of developing Parkinson's disease.
Exclusion criteria:
- Individuals with self-reported Parkinson's Disease or dementia will not be eligible.
Updated on
13 Feb 2025.
Study ID: 2004396886, MMGE-MJFF-PPMIREMOTE
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