Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM)

Studying the Connection Between Sudden Pancreas Inflammation and Diabetes

E
Evan Fogel, MD

Primary Investigator

Enrolling By Invitation
18 years - 75 years
All
Phase N/A
100 participants needed
3 Locations

Brief description of study

Researchers at Indiana University School of Medicine are conducting a study to find out how many people with acute pancreatitis develop diabetes. Diabetes is a known complication of acute pancreatitis. For some people, diabetes can last a few weeks after acute pancreatitis, but for others, it can appear a year or more after having acute pancreatitis. No one knows why some people go on to develop diabetes while others don't.
 
People with acute pancreatitis will be compared to people who already had diabetes before their acute pancreatitis attack to better understand diabetes after acute pancreatitis and whod risk of developing it, as well as the different types of diabetes. 
 
THIS STUDY IS ENROLLING BY INVITATION ONLY - potentially eligible participants will be recruited from multiple IU health and Eskenazi health locations and contacted directly by the study team only.
 

Detailed description of study

Year 1: Three study visits in the first year; two in-person and one remote
Year 2: Two study visits and then one each year following (for up to 5 years)
  • Each study visit lasts about 3 hours and all study visits take place at University Hospital CRC in Indianapolis, IN
  • Participants are asked to do metabolic testing once a year where blood is drawn at certain time points; they also complete surveys at each visit

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Acute pancreatitis, Diabetes
  • Age: 18 years - 75 years
  • Gender: All

Inclusion Criteria:
1.    Age 18 - 75 years at the time of enrollment
2.    Diagnosis of Acute Pancreatitis (AP) 0 - 90 days prior to enrollment date

This study investigates how acute pancreatitis, a sudden inflammation of the pancreas, is related to the development of diabetes. Diabetes is a disease that affects how the body uses sugar and is known to sometimes occur after acute pancreatitis. However, it is unclear why some people develop diabetes after this condition while others do not. To explore this, researchers will compare people who have had acute pancreatitis with those who already had diabetes before their pancreatitis attack.

Participants in the study will attend visits where they will undergo metabolic testing, which involves drawing blood at specific times to measure how the body processes sugar. They will also complete surveys during each visit. The study will be conducted over several years, with visits taking place at the University Hospital CRC in Indianapolis, IN. Each visit is expected to last about three hours.

  • Who can participate: Adults aged 18 to 75 years who have been diagnosed with acute pancreatitis within the last 90 days are eligible to participate.
  • Study details: Participants will undergo metabolic testing and complete surveys. The testing involves drawing blood at specific times to see how the body processes sugar.
  • Study visits: The study requires 3 visits in the first year, 2 in the second year, and 1 visit each year after for up to 5 years.
Updated on 06 Mar 2026. Study ID: GI-NIH-DREAM, 11902
Please visit our main page to search for other studies you may be interested in. If you need help finding a study or have any questions, please contact us at inhealth@iu.edu

Interested in the study?

This study is accepting only persons who receive care at a certain clinic or doctor or who are part of an invited group. Questions about this study can be directed to the study team listed in the description or contact your doctor to see if you are eligible.

Accepting Referrals by Invitation Only