APOLLO: A Randomized Phase II Double-Blind Study of Olaparib versus Placebo Following Curative Intent Therapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

A
Anita Turk

Primary Investigator

Enrolling By Invitation
18-100 years
All
Phase 2
1 Location

Brief description of study

The purpsoe of this study is to determine the relapse-free survival (RFS) benefit from the addition of a maintenance olaparib following completion of chemotherapy in patients with resected pancreatic carcinoma and a pathogenic germline or somatic mutation in BRCA1, BRCA2 or PALB2.

Eligibility:

  • Patient must be ≥18 years of age on day of consent.
  • Patient must have an ECOG Performance Status of 0-2.
  • Patient must have a diagnosis of pancreatic cancer and have successfully undergone a curative intent surgical resection and must have no evidence of recurrent disease as determined by the investigator.
  • NOTE: This includes patients with adenocarcinoma, acinarcarcinoma, squamous cell carcinoma adenosquamous and variants thereof. Patients with neuroendocrine tumors are excluded from enrolling.
  • Additonal criteria must be met based on determination by Investigator and study requirements

 

Detailed description of study

 

NCT ID: NCT04858334

 

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: pancreatic cancer
  • Age: Between 18 Years - 100 Years
  • Gender: All
Updated on 01 Aug 2024. Study ID: 15207
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