Simultaneous Prospective Kidney Transplant assessment in Combined Liver Kidney Candidates (RECOVERY) Study

Investigating Kidney Function Recovery in Patients Undergoing Both Liver and Kidney Transplants

Primary Investigator
M
Muhammad Jan

Primary Investigator

Administratively Closed
18 years - 100 years
All
Phase N/A
15 participants needed
1 Location

Brief description of study

The purpose of the study is to determine how much a persons kidney function recovers after receiving a simultaneous liver kidney transplant. We are interested to see if a liver transplant alone makes it unnecessary to perform a kidney transplant. 
 
THIS STUDY IS ENROLLING BY INVITATION ONLY - This study is enrolling acute kidney injury (AKI) patients who are 18 years of age and who are listed to receive a simultaneous liver kidney transplant to look at function recovery.

Detailed description of study

Participation involves completing two nuclear medicine scans (one prior to liver and kidney transplant and one 10 months later) 

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Liver disease, Acute kidney injury (AKI)
  • Age: 18 years - 100 years
  • Gender: All

Inclusion Criteria:
  • Must be 18 years of age or older
  • Must be diagnosed with end stage liver disease and acute kidney injury (AKI)
  • Will be having SLK surgery at Indiana University (IU) School of Medicine /IU Health Transplant as part of standard medical care.  
Exclusion Criteria:
  • Unstable patients (e.g. in the ICU or those who are on Continous Renal Replacement Therapy (CRRT) who cannot complete the nuclear medicine scan or those with AKI on Hemodialysis
  • Prior history of any solid organ transplant.
  • Those who are currently pregnant or breast feeding.

This study investigates how kidney function recovers after a person receives both a liver and a kidney transplant. The purpose of this study is to see if having a liver transplant alone can improve kidney function enough that a kidney transplant might not be needed. This study is for people with acute kidney injury, which is a sudden decrease in kidney function, and end-stage liver disease, which is the final stage of chronic liver disease.

Participants will have two nuclear medicine scans. A nuclear medicine scan is a test that uses small amounts of radiation to create pictures of the kidneys and takes about 40 minutes. The first scan happens before the transplant, and the second scan happens 10 months later. The results of these scans will be compared to see how much kidney function has improved.

  • Who can participate: Participants must be 18 years or older and have end-stage liver disease and acute kidney injury. They must be scheduled for a simultaneous liver-kidney transplant at Indiana University School of Medicine.
  • Study details: Participants will undergo two nuclear medicine scans to assess kidney function recovery. These scans use small amounts of radiation to create images of the kidneys.
  • Study timelines: The study will last 10 months.
Updated on 06 Jul 2026. Study ID: NEPH-IIR-RECOVERY, 15853

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