Healthy Females Needed To Help Develop A Vaccine for Chlamydia (IMPACT Study)

S
Stephen Jordan

Primary Investigator

Healthy Females Needed To Help Develop A Vaccine for Chlamydia (IMPACT Study)
Recruiting
18 years - 40 years
Female
Phase N/A
30 participants needed
1 Location

Brief description of study

Chlamydia trachomatis (CT) is the most reported bacterial sexually transmitted infection (STI) in the United States. Untreated chlamydia infection in women can result in pelvic inflammatory disease, infertility, and/or ectopic pregnancy. 

Although chlamydia rates are at an all-time high, no vaccine is available because we don't yet understand how immunity to chlamydia develops. The IMPACT study is a case-control study of women who are either chlamydia-naive (control group) or chlamydia-exposed (case group). The overall goal of the study is to understand how immunity develops to chlamydia so we can design a vaccine to protect women from infertility, pelvic inflammatory disease, and ectopic pregnancies. 

We are recruiting healthy women aged 18-40 who have never had chlamydia before to be part of the control group. You will not be exposed to chlamydia or given any vaccine; we are simply collecting blood, swabs, and genital specimens as part of the control group.

This study has the potential to inform whether we should or should not be screening for gastrointestinal CT infections in women who have no symptoms, and also determine if an oral CT vaccine may be feasible in the future. 

Detailed description of study

  • Healthy control participants who meet eligibility criteria will be recruited from the Indianapolis community.
  • Survey: Participants will complete a brief survey asking about their sexual history and obtaining other clinical data. While completing the survey and answering questions about sexual behavior, subjects will be advised they can skip any questions that make them uncomfortable.
  • Sample collection: all collections (including blood draws, oral/vaginal/rectal swabs, and genital specimens) will be done by trained personnel using sterile procedures. All samples will be de-identified.

Immune-mediated Protection against Chlamydia trachomatis (IMPACT) Study: A Case-control study

For more information, click the link below:

IMPACT Study Details

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Healthy
  • Age: 18 years - 40 years
  • Gender: Female

To be eligible, the following must ALL be true about you:
·         Woman aged 18-40
·         Have not had receptive anal sex (a penis in your rectum) within the last year
·         Have not had chlamydia before
·         Have NOT used antibiotics that can kill chlamydia within the last 30 days (levofloxacin, doxycycline, azithromycin)
·         Are NOT infected with HIV or syphilis
·         Are NOT currently pregnant
·         Have NOT been diagnosed with an abdominal disease, like Crohn’s, irritable bowel disease, etc.
·         Have NOT had a hysterectomy
·         Have NOT been diagnosed with a serious psychiatric illness
·         Do NOT identify as trans-gender
·         Have valid contact information
·         Have a smart phone that can receive texts
·         Are NOT allergic to tetracycline antibiotics, like doxycycline

Updated on 10 Jul 2025. Study ID: INFD-IIR-RECTAL-CT, 19705

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