Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries
J
Jodi Skiles
Primary Investigator
Enrolling By Invitation
All
Phase
N/A
99999999 participants needed
2 Locations
Overview
The primary purpose of the Research Sample Repository is to make blood samples available forh studies related to histocompatibility and hematopoietic cell transplantation (HCT)her cellular therapy.
Representatives of participating centers and investigators or research groups may requesth samples contained in the Research Sample Repository for the purpose ofducting research including:
- investigating molecular explanations for histocompatibility or clinical outcomes throughysis of genomic, epigenetic, or other biomolecular data
- evaluating the factors that affect transplant or cellular therapy outcome
- studying the distribution of HLA tissue types in different populations
- studying the success of transplantation, cellular therapies or supportive care in thegement of marrow toxic injuries
- performing de-linked (anonymous) research
Description
Research samples will be accepted from the following four categories:
- Hematopoietic Cell or other Cellular Therapy Donors
- Cord Blood Units
- Hematopoietic Cell Transplantation or other Cellular Therapy Recipients
- Patients with Marrow Toxic Injury
Eligibility
You may be eligible for this study if you meet the following criteria:
-
Conditions:
Autologous Stem Cell Transplantation, Allogeneic Stem Cell Transplantation, Cellular Therapy, Marrow Toxic Injury
-
Gender: All
Eligibility to participate in the Research Sample Repository Protocol:
Hematopoietic Cell (HC) or Other Cellular Therapy Donors
- Donors are eligible to participate in the Research Sample Repository if they havedonated or are scheduled to donate HCs or cellular therapy products to an allogeneicher by a marrow harvest or by apheresis. This includes adults with andwithout decision making capacity and children.
- All donors registered on the National Marrow Donor Program (NMDP) Registry, regardlesswhether they have been requested to donate a product for a patient, are eligible tohe Research Sample Repository.
Cord Blood Units (CBUs)
- Testable material from CBUs (Specimens) infused at treatment centers covered under theC. W. Bill Young Transplantation Program are eligible for inclusion in the ResearchRepository. Material may be submitted by participating treatment centers,zed laboratories and Cord Blood Banks.
Hematopoietic Cell Transplantation or Other Cellular Therapy Recipients
- All U.S. recipients of allogeneic or autologous HC transplants or cellular therapiesgible to participate in the Research Sample Repository. This includes adultswith and without decision making capacity and children.
Patients with Marrow Toxic Injury
- Any patient who is treated for a marrow toxic injury at a center participating in theDP's Radiation Injury Treatment Network (RITN) is eligible to participate in theResearch Sample Repository. This includes adults with and without decision-makingy and children.
- Eligible patients may have received support care only, growth factor support,hematopoietic stem cell transplant or other appropriate medical treatment for marrowjury
Updated on
13 May 2024.
Study ID: NMDP IRB-1991-0002
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