What Will Happen During Study Participation?

• If you agree to be in the study, you will undergo a urodynamic testing procedure and allow the collection of continuous ECG, nerve recordings from your skin, and skin temperature during your procedure. These recordings will be obtained from standard electrodes that will be placed on the skin and from a smart watch that you will wear on your wrist. As part of the urodynamic testing, a catheter will be placed in your bladder and your bladder will be filled with saline, which commonly induces autonomic dysreflexia in persons with tetraplegia. The saline will be immediately drained from your bladder once you experience symptoms of autonomic dysreflexia. This testing could take up to a maximum of 30-45 minutes.
• One symptom of autonomic dysreflexia is an increase in blood pressure. While this typically improves after draining the bladder or changing position, this symptom may persist. If symptoms of high blood pressure persist after draining your bladder and changing position, you may be given Nifedipine (10 mg tablet) to return your blood pressure to normal range.
• You will be asked to self-report the symptoms that you feel.  We will also ask you to complete questionnaires afterward regarding symptoms you’ve experienced. We will also be collecting information from your medical records.  This will help us to understand the nerve recordings that will be making.
• The total time these procedures will take will be approximately 1 hour and 30 minutes.