Healthy Volunteers Needed For Ankle Fracture and Pain Study!
Kelly Naugle
Primary Investigator
Roman Natoli, MD
Primary Investigator
Fletcher White
Primary Investigator
Brief description of study
What is this study about?
The purpose of this study is to teach us more about why some people often experience persistent pain after having a bone fracture. We want to determine whether certain factors place individuals more at risk for experiencing persistent pain after a bone fracture including pain sensitivity and inflammation.
We are comparing measures of pain sensitivity to heat, cold and pressure stimuli, levels of inflammation in the blood, and patterns of blood flow in ankle fracture patients to healthy individuals who have not experienced a bone fracture.
Who can take part?
Healthy Volunteers who have never had a bone fracture.
Detailed description of study
What is involved during study participation?
You will be asked to participate in one study visits located in the Clinical Research Center at Goodman Hall (across the street from Methodist Hospital) at IU-Indianapolis in Indianapolis, IN.
The study visit should last no more than approximately 1.5 hours.
During the study visit, you will complete the following procedures:
1) questionnaires assessing your health, pain, psychological status, sleep, physical function, and coping styles
2) a blood draw,
3) a thermal camera (shows patterns of heat and blood flow) will take an image of your ankle,
4) sensory (feeling) tests on your lower and upper extremities (hands and feet/ankles). During the sensory tests, you are likely to experience pain and they may be perceived as unpleasant; however, the pain is temporary.
Incentive/Compensation
- Compensation will be provided in the form of gift cards ($50 for completing all of the study requirements).
- Participants will receive these cards at the end of the study session or through mail or email.
- Participants will receive a parking validation ticket to cover the expenses of parking.
Additional information:
Study title: The prevalence of neuropathic pain pathophysiology associated with ankle fracture
The study is being conducted by Dr. Fletcher White, Dr. Roman Natoli, and Dr. Kelly M. Naugle. Dr.’s White and Natoli are affiliated with the Indiana University School of Medicine. Dr. Naugle is affiliated with the School of Health and Human Sciences at IUI. It is funded by the Department of Defense.
To learn more about PI Fletcher White, PhD and his research interests, please visit this link: https://medicine.iu.edu/faculty/20353/white-fletcher
To learn more about Co-I Roman Natoli, MD, PhD and his research interests, please visit this link: https://medicine.iu.edu/faculty/27184/natoli-roman
To learn more about Co-I Kelly Naugle, PhD and her research interests, please visit this link: https://shhs.iupui.edu/contact/directory/naugle-kelly.html
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Healthy
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Age: 18 years - 85 years
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Gender: All
Exclusion criteria:
- History of bone fracture
- Chronic pain or an ongoing pain condition
- Current pain medication usage
- Any previous orthopaedic surgical procedures
- Free of any surgeries for at least 5 years
- Peripheral neuropathy
- You have a major disease including: cardiovascular disease, metabolic disease, renal disease, neurological disease, or serious psychiatric condition
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