Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients with Symptomatic Sickle Cell Disease
Jodi Skiles
Primary Investigator
Brief description of study
Detailed description of study
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: sickle cell disease, Riley
-
Age: 5 years - 45 years
-
Gender: All
Inclusion Criteria
Adequate physical function
Must have a first-degree related HLA-haploidentical related donor who is willing and able to donate blood marrow
Exclusion Criteria
Participants who have an HLA-matched sibling who is able and willing to donate bone marrow
Uncontrolled bacterial, viral or fungal infection in the 6 weeks before enrollment
Evidence of HIV infection or known HIV positive serology
Participants who have received a previous HCT
Participants who have participated in another clinical trial in which the patient received an investigational or off-label use of a drug or device within 3 months of enrollment
Females who are pregnant or breastfeeding
Participants with clinically significant, uncontrolled autoimmune diesease, requiring active medical management, which, in the judgment of the local Principal Investigator, indicates that the patient could not tolerate transplantation
Additional Information:
