Preventing cervical cancer in HIV-infected Kenyan and Ugandan women

Enrolling By Invitation
21-60 years
Female
Phase N/A

Brief description of study

What is the purpose of this study?
This study is an extension of our research team’s successful collaborations between Indiana University and Moi University, and now includes the Infectious Diseases Institute (Uganda). We have developed new aims to help in the fight against cervical cancer by: 1) evaluating HR-HPV DNA testing of self-collected vaginal swabs combined with VIA in screening for cervical cancer in HIV-infected women in Kenya/Uganda, and 2) determining the role of aflatoxin in HR-HPV detection and persistence among HIV-infected Kenyan and Ugandan women.

THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate clinical trial(s) at the time of their routine clinic visit. Occasionally, a patient may be a self-referral or physician referral, but are still screened for appropriate clinical trials at the time of their routine clinic visit. PI and staff may send copies of relevant consent forms to these patients to look over prior to actually consenting or enrolling them. This may take place at the patient's visit at which the consent is presented or the patient's next visit to the outpatient hematology/oncology clinic.

Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:
IU Clinical Trials Office 
Phone: (317) 278-5632

Detailed description of study

This study aims to better understand the natural history of HPV infection (HPV is a virus that can cause cervical cancer) and cervical cancer and to determine how to best screen for cervical cancer and to identify cofactors in addition to HIV that are involved. It also aims to understand if aflatoxin (a chemical produced by mold commonly found in Uganda and Kenya) is an additional risk factor for cervical cancer among HIV-infected Kenyan and Ugandan women.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: HIV, Cervical Cancer
  • Age: Between 21 Years - 60 Years
  • Gender: Female

Inclusion Criteria:
  • Kenyan women living in or within 30 km of Eldoret who present for cervical cancer screening at the CCRP, and Ugandan women who live within 30 km of Mulago who present for cervical cancer screening at the UCI/IDI clinic
  • Willing to return for four total visits over a three-year total period 
Exclusion Criteria:
  • Women who are currently pregnant
  • Inability to consent due to mental or physical disability, or a medical illness that has rendered the patient unable to attend annual visits. 

Updated on 01 Aug 2024. Study ID: 11449, U54-IUSCCC-0761
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