Non-invasive quantification of fractional flow reserve (FFR) based on Coronary CT Angiography and Echocardiogram for Coronary Stenosis
J
Jeffrey Breall, MD, PhD
Primary Investigator
Enrolling By Invitation
18-80 years
All
Phase
N/A
15 participants needed
1 Location
Brief description of study
The purpose of this study is to validate a non-invasive method to assess fractional flow reserve. Our Hypothesis is that correlation between Fractional Flow Reserve and volume reduction (VR) of vessel lumen will reveal the ischemic severity of a coronary stenosis with volume reduction through two thresholds (VRm and VRs). Subjects will undergo a coronary CT angiogram and echocardiogram. They will also have measurements of the pressure waves taken during the catheterization. Researchers will also collect demographic information, vital signs, and lab results from subjects as well.
Detailed description of study
• Acquire CCTA and ECHO imaging data prior to coronary angiogram and the central aortic pressure wave during the coronary angiogram before and after possible stenting.
• Data collection via completion of the case report form (CRF).
• Anatomically extract the aortocoronary arterial system from CCTA image data and blood flow wave forms from ECHO image data.
• Computationally quantify the 4-D (space+time) in vivo pressure in the aortocoronary arterial system.
• Quantitatively compare the central aortic pressure wave between computational results and invasive measurement.
• Identify the thresholds of VRm and VRs on FFR-VR curve and determine the severity of the existing coronary stenosis (mild, moderate, or serve) via a parametric study
• Compare the computed severity with clinical reports.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Hypertension
-
Age: Between 18 Years - 80 Years
-
Gender: All
Inclusion Criteria:
- •Any patient going for clinically indicated diagnostic left heart cardiac catheterization and coronary angiography.
- Patients > 18 years of age and < 80 years of age.
- •Patients able to understand the purpose of, and procedures for, the study and signs informed consent.
Exclusion Criteria:
- Serum creatinine > 1.7 within the last 6 months
- aortic stenosis
- GFR < 40 within the last 6 months
Updated on
01 Aug 2024.
Study ID: 1908594159, KIC-IIR-BREALL-STENOSIS
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