Hypoesthesia Related Neurotrophic Keratitis in Patients with Ocular Graft Versus Host Disease
S
Shaohui Liu, MD
Primary Investigator
Enrolling By Invitation
100 years and younger
All
Phase
N/A
30 participants needed
1 Location
Brief description of study
Hypothesize that the recalcitrant nature of ocular
GVHD may be related to corneal nerve damage and corneal hypoesthesia. We aim to
study the prevalence of corneal hypoesthesia in GVHD patients and its
correlation with ocular surface changes.
Detailed description of study
We plan to study the corneal sensation changes and their correlation with ocular surface staining, tear film breakdown and meibomian gland dysfunction in GVHD patients. Our study will shed light on an important aspect of corneal innervation damage in GVHD and may lead to new treatment modalities for those patients, noting that topical recombinant human nerve growth factor cenegermin was recently FDA approved for neurotrophic keratopathy. We intend to identify the ocular characteristics of GVHD patients that may potentially benefit from cenegermin treatment.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: GVHD, Corneal hypoesthesia
-
Age: - 100 Years
-
Gender: All
Inclusion Criteria:
- Chronic GVHD is diagnosed based on the history of allogeneic HSCT and the presence of systemic GVHD in organs other than the eye. In the ocular GVHD group, dry eye symptoms start after the development of systemic GVHD. If post-HSCT dry eye precedes GVHD clinical signs in other organs, we will use the 2013 diagnostic criteria by International chronic ocular GVHD consensus group.
Exclusion Criteria:
- exclude patients with a history of herpetic simplex or zoster keratitis, ocular or neurologic surgery (including laser or refractive surgical procedure) within 3 months before enrollment, trauma, diabetes with signs of peripheral neuropathy. We will also exclude patients with active corneal thinning or infection.
Updated on
01 Aug 2024.
Study ID: 2004207079, OPTH-IIR-GVHD
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