Serum Protein-Based Indices for the Progression of Fracture Healing and Nonunion
R
Roman Natoli, MD
Primary Investigator
Enrolling By Invitation
18-70 years
All
Phase
N/A
180 participants needed
1 Location
Brief description of study
To define a serum protein-based diagnostic for the progression and failure of fracture healing, through the identification of a set of serum proteins that appear at early times of biological healing and show a specific correlation with later radiological and functional signs used to define delayed healing and non-union.
Detailed description of study
The purpose of this observational study is to identify a set of proteins in the blood that appear when a fracture is healing. This protein identification will be sued in conjunction with other methods of monitoring healing, including radiological and functional signs, to help diagnose delayed healing and non-union of a fracture in future patients.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Fracture Healing
-
Age: Between 18 Years - 70 Years
-
Gender: All
Inclusion Criteria:
- 2. Diagnosis of isolated closed extra-articular fractures of the humeral shaft deemed appropriate for closed treatment by immobilization and a sling by the treating physician
Exclusion Criteria:
- 1. Humeral shaft fractures that extend into the articular surface.2. Pathologic fractures.3. Additional long bone injuries or fractures of upper or lower extremity that would compromise outcome assessments of single fracture protein levels.4. Previous retained hardware in humerus from other injuries.
Updated on
01 Aug 2024.
Study ID: 2011653915, 00237830
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