Post-Intensive Care Syndrome – pediatrics (PICS-p)
C
Courtney Rowan, MD
Primary Investigator
Administratively Closed
1 months - 17 years
All
Phase
N/A
500 participants needed
1 Location
Brief description of study
This study is a first step in addressing this critical knowledge gap. Here, we conduct PICS-p, a prospective longitudinal cohort study of 500 patients experiencing 3 days of intensive care therapies (case) during their first PICU hospitalization at one of approximately 30 U.S. PICUs to evaluate child and family outcomes over two years; specifically, we will collect information about the subject’s baseline, PICU course of illness, and status at PICU discharge, then at 2 and 6 weeks, and 3, 6, 9, 12, 18, and 24 months after PICU discharge. We will compare outcomes of these PICU patients with a control group of 250 patients frequency matched on age, sex, and medical complexity34 who received an overnight PICU stay and no intensive care therapies, as well as with published HRQOL data from the general35 and chronically ill populations.36,37
Detailed description of study
a prospective longitudinal cohort study of pediatric patients experiencing 3 days of intensive care therapies (case) at one of approximately 30 U.S. PICUs to evaluate child and family outcomes over two years post-PICU discharge. We will compare outcomes of these PICU patients with a control group of patients who received an overnight PICU stay (control) but did not receive intensive care therapies, as well as with published quality of life data from the general and chronically ill populations. Children and their families will be enrolled locally from each PICU, their baseline data will be collected by local research staff, and their post-discharge outcomes will be followed centrally from the University of Pennsylvania and the Seattle Children’s Research Institute. Our specific aims are (1) to determine the physical, cognitive, emotional, and social health outcomes and trajectory of recovery in a population of children post-critical illness; (2) to determine the baseline health, presenting problem, and PICU factors associated with impaired physical, cognitive, emotional, and social outcomes among PICU survivors, and (3) to determine the emotional and social health outcomes in parents and siblings of PICU survivors. Our primary goal is to explicate the impact of pediatric critical illness over a two-year period of time to guide future intervention research to optimize child and family outcomes. Our overall goal is to improve the health and well-being of PICU survivors and their families.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: PICU patients, Riley
-
Age: 1 months - 17 years
-
Gender: All
Inclusion Criteria:
- 1. Current admission is the child’s first PICU admission
- 2. Patient age ≥4 weeks and ≥44 weeks corrected gestational age and <16 years (has not yet reached 16th birthday) on PICU admission
- 3. At least one parent/legal guardian (≥18 years of age or considered emancipated) living with the potential subject
- 4. PICU LOS of 3 days (covering at least 3 nights from midnight to 7am) in which the patient received intensive care therapies for organ dysfunction (invasive mechanical ventilation, vasopressors/inotropes, acute renal replacement therapy, or other extracorporeal therapies).
- 5. Anticipated patient discharge to home (direct or indirect)
Exclusion Criteria:
- 1. Patient history of neonatal intensive care unit hospitalization
- 2. Life expectancy not anticipated to be more than one year (e.g., active do not resuscitate [DNR] plan or actively managed by the palliative care team for end-of-life symptom management)
- 3. Patient in foster care or ward of the state
Updated on
18 Nov 2024.
Study ID: PICU-CHOP-PICS-P, 2010341025, 0001252
