Exhaled Breath Volatile Organic Compounds as Biomarkers for Pulmonary Exacerbation
M
Mike Davis
Primary Investigator
Administratively Closed
8 years - 60 years
All
Phase
N/A
100 participants needed
1 Location
Brief description of study
We will obtain and measure exhaled VOCS in subjects
with CF. We hypothesize that exhaled VOCs will differ between baseline and PEx in subjects with CF.
Detailed description of study
1.1.1 To
compare exhaled VOCs between subjects with CF experiencing PEx and subjects with CF at baseline.
1.1.2 To
collect and analyze exhaled VOCs from subjects with CF longitudinally during
different states of pulmonary health, including throughout the course of PEx.
1.2
Secondary
Objective
1.2.1 To
establish normative ranges of exhaled VOCs in subjects with CF.
1.2.2 To
establish within-subject variability in exhaled VOCs in subjects with CF.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: cystic fibrosis
-
Age: 8 years - 60 years
-
Gender: All
Inclusion Criteria:
- Aged 8-60 with a diagnosis of cystic fibrosis
- Able to provide written informed consent (and assent when applicable) themselves or via a legal representative
- Able to perform acceptable and reproducible spirometry and other requirements of the study
Exclusion Criteria:
- • That are unable or unwilling to cooperate with specimen collection.
- • That have a condition or abnormality that in the opinion of the Investigator would compromise the safety of the subject or the quality of the data.
- • That have a history of solid organ transplant
Updated on
29 Sep 2025.
Study ID: PPUL-IIR-PEX, 12005
