Pilot trial to determine Relationship between Troponin Kinetics and Hemorrhagic MI
R
Rohan Dharmakumar
Primary Investigator
Enrolling By Invitation
100 years and younger
All
Phase
N/A
30 participants needed
1 Location
Brief description of study
This
study is a prospective, cohort study to determine the quantitative threshold
differences in troponin-I level between hemorrhagic and non-hemorrhagic
myocardial infarction (MI).
Detailed description of study
2.1
Primary Objective
To evaluate the clinical translatability of
troponin kinetics towards identification of threshold level for hMI.
2.2
Secondary Objective
To evaluate the clinical translatability of
troponin kinetics to identify infarct expansion
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: myocardial infarction
-
Age: - 100 Years
-
Gender: All
Inclusion Criteria:
- 2. Index Anterior wall STEMI, based on:
- a. Symptoms of myocardial ischemia (such as chest pain, shortness of breath, jaw pain, arm pain, diaphoresis, or any anginal equivalent) and
- b. ECG criteria: New or presumed new ST-segment elevation at the J point in two or more contiguous leads with the cut off points ≥0.2 mV in leads V1, V2, V3 or V4 and ≥0.1 mV in other leads OR new left bundle branch block (LBBB)
- c. Coronary angiogram with evidence of total or subtotal occlusion of the left anterior descending coronary artery (LAD)
- 3. Coronary angiogram with PCI to occur irrespective of the onset of the symptoms.
- 4. Ability to provide informed consent for themselves
Exclusion Criteria:
- 1. History of prior myocardial infarction,
- 2. Cardiogenic shock,
- 3. Patients who present with current cardiac arrest
- 4. Any contraindication to cardiac CMR (claustrophobia, pacemaker or cardiac defibrillator, known allergy to gadolinium),
- 5. Presence of permanent atrial fibrillation,
- 6. Unconscious patient,
- 7. Severe renal insufficiency (creatinine clearance ≤ 30 ml/min/m2 or renal replacement therapy),
- 8. Women who are pregnant or breastfeeding. Women of reproductive potential must have a negative pregnancy test.
Updated on
01 Aug 2024.
Study ID: 13081, KIC-IIR-DHARMAKUMAR-13081
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