Bone fragility determinants among children with T2D in comparison to healthy controls.
L
Linda DiMeglio, MD
Primary Investigator
Enrolling By Invitation
5-21 years
All
Phase
N/A
60 participants needed
2 Locations
Brief description of study
To define the prevalence of fracture among children with T1D and T2D and compare the prevalence among the two groups of diabetes.
Detailed description of study
a) To evaluate the bone health in children with T2D (assess bone mineral density, bone microarchitecture and bone turnover markers) and to compare those parameters to data from sex, age, and gender-matched healthy children.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: T2 Diabetes, Riley
-
Age: Between 5 Years - 21 Years
-
Gender: All
Inclusion Criteria:
- For all participants:
- a) Children and adolescents aged 5-21 years with T2 diabetes
- b) Willing to participate attend a study visit in the Musculoskeletal FIT Core for measures of bone density and physical function (IRB study #1707550885)
- c) Consent to participate
- Additional Criteria for Healthy Controls
- a) Non-diabetic children
Exclusion Criteria:
- a. Other form of diabetes (monogenic forms of diabetes, steroid induced diabetes, CFRD)
- b. Pregnant or lactating
- c. The presence of severe chronic kidney disease
- d. The presence or history of diseases and syndromes associated with low BMD (i.e., non-compensated hypothyroidism, hyperthyroidism, hyperparathyroidism, intestinal malabsorption, inflammatory bowel disease, or history of malignancy).
- e. The intake of drugs that can influence bone metabolism
- f. Any specific metabolic bone disorder (osteogenesis imperfecta, rickets, etc.)
- g. The presence of acute infectious disease.
Updated on
13 Sep 2024.
Study ID: 16350, PENDO-IIR-BONE-FRAGILITY-T2D
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