Biomarkers of Brain Injury in Children on ExtrAcorporeal Membrane Oxygenation.
M
Matthew Friedman, MD
Primary Investigator
Enrolling By Invitation
2-18 years
All
Phase
N/A
50 participants needed
1 Location
Brief description of study
The BEAM study is a multicenter, prospective, observational study in children supported on extracorporeal membrane oxygenation (ECMO). The primary goals of this study are to develop and refine a brain injury multimarker panel for accurate neurologic monitoring at the bedside and early classification of mortality and disability outcomes of critically ill children supported on ECMO.
Detailed description of study
1. Determine if circulating levels of brain injury markers during ECMO and brain MRI abnormalities within 6 weeks after ECMO are associated with survival at 18 months after ECMO with a score ≥85 on the Vineland Adaptive Behavior Scales, third edition (VABS-III).
2. Determine whether the presence and degree of inflammation during ECMO and markers of neuroinflammation on brain MRS within 6 weeks after ECMO are associated with survival at 18 months after ECMO with a score ≥85 on VABS-III.
3. Determine whether metabolic and lipid neuroinflammatory pathways will distinguish between at-risk for, acute, and recovery phases of neurologic injury (NI) during ECMO.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Brain injury, Riley
-
Age: Between 2 Days - 18 Years
-
Gender: All
Inclusion Criteria:
- All children (2 days to <18 years) cannulated onto ECMO and admitted to a pediatric or cardiac ICU at participating institutions.
Exclusion Criteria:
- CMO cannulation at an outside institution with transport to a study site >24 h after ECMO initiation; limitation of care (e.g., family planning to withdraw support) or brain death evaluation within 24 h of ECMO cannulation; inability to speak or understand English or Spanish; and pregnancy.
Updated on
13 Sep 2024.
Study ID: 1910680305, PICU-JHOPKINS-BEAM
Please visit our main page to search for other studies you may be interested in.
If you need help finding a study or have any questions, please contact us at inhealth@iu.edu
