Reactive Oxygen Species in Respiratory Failure, Delirium, and Post-ICU Cognitive Impairment
S
Sikandar Khan, MD
Primary Investigator
Enrolling By Invitation
18-100 years
All
Phase
N/A
25 participants needed
3 Locations
Brief description of study
The purpose of this study is to better understand the relationship between being ill and the release of chemicals that go up with stress using blood samples. We will also measure physical and mental recovery of patients after being admitted to the Intensive Care Unit (ICU).
Detailed description of study
Participants will be asked to allow researchers to collect blood samples three times during their hospital stay and answer a few brief questions. They will ask participants to complete a few follow up study visits after the participant is discharged. During the study visits, participants will complete questionnaires about mood, thinking and memory activities, and measurements of muscle strength. Researchers will also ask a family member to complete a few questionnaires about the participant's memory and daily activities prior to hospitalization.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: reactive oxygen species, respiratory failure, delirium
-
Age: Between 18 Years - 100 Years
-
Gender: All
Inclusion Criteria:
- Admitted to the ICU with acute respiratory failure: Acute respiratory failure includes need for invasive mechanical ventilation, non-invasive positive pressure ventilation, supplemental oxygen via a non-rebreather mask, or nasal cannula delivering heated high flow oxygen, or clinical notes indicating diagnosis of acute respiratory failure.
Exclusion Criteria:
- Admitted with acute central nervous disorder, ischemic or hemorrhagic stroke, traumatic brain injury, or chronic neurologic injury including anoxia
- Admitted with acute alcohol or drug intoxication or withdrawal
- Admitted with central nervous infection or neoplasm
- History of neurodegenerative disorder including Alzheimer’s Disease, Parkinson’s, or dementia, or on any anti-dementia medications
- History of pre-existing mild cognitive impairment
- Immunocompromised with central nervous system sequelae
- Recent substantial ICU exposure (invasive mechanical ventilation in the past 2 months, or greater than 5 days in the ICU in the past month) or cardiac surgery in the past 3 months
- Severe uncontrolled bipolar disorder or schizophrenia
- Severe vision, hearing, motor/mobility, or communication impairment which prevents cognitive assessments
- In treatment for vasculitis or other disorders associated with chronic inflammation
- Homeless, or without phone number or mailing address making participation for follow up assessments difficult
- Pregnant or nursing
- Incarcerated
- Unable to communicate in English (exclusion due to validation of instruments in English)
- Patients living far outside of Indianapolis region and unable to travel to Indianapolis for follow up
- Prolonged duration of acute respiratory failure prior to enrollment in the study
Updated on
01 Aug 2024.
Study ID: 16232, PULM-IIR-ROS-DELIRIUM
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