Isolating PAECs
M
Micheala Aldred
Primary Investigator
Enrolling By Invitation
18-89 years
All
Phase
N/A
50 participants needed
2 Locations
Brief description of study
The primary outcome measure will be the success rates of isolating PAECs from PACs and comparing between the different methods (balloon tip versus aspirated blood), between PH subtypes, and then PH patients and control patients using demographic and objective data obtained from our cohort.
Detailed description of study
The purpose of this study is to collect endothelial cells from the lung vessels of pulmonary hypertension (PH) patients during a right heart catheterization (RHC) procedure. Normally, these cells can only be obtained if the patient has a lung transplant. This means the number of samples is limited, and only end-stage disease can be studied. The goal of this study is to reproduce the results from publications that have isolated these cells during routine diagnostic RHC procedure. We will then compare the characteristics of these cells across different types of PH, to help us better understand what changes happen in the early stages of PH. The laboratory studies will include looking at variations in the genetic code (DNA), and in the amount of the message (RNA) and the proteins that genes produce.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: pulmonary hypertension
-
Age: Between 18 Years - 89 Years
-
Gender: All
Inclusion Criteria:Any adult (men or women) 18 years of age or older who is scheduled for right heart catheterization will be eligible for enrollment. Those with a known diagnosis of PH will be enrolled as prevalent patients. Those who do not have a prior diagnosis of PH will be enrolled into either the patient or control arm of the study, dependent on the outcome of the RHC. Patients meeting diagnostic criteria for PH will be enrolled as incident patients, while those who do not have PH will be enrolled as controls.
Exclusion Criteria:
- Pregnancy
Updated on
01 Aug 2024.
Study ID: 2009643095; PULM-IIR-ISOLATING-PAECS
Please visit our main page to search for other studies you may be interested in.
If you need help finding a study or have any questions, please contact us at inhealth@iu.edu
