Sympathetic Nerve Activity and Cardiovascular Events
T
Thomas Everett
Primary Investigator
Enrolling By Invitation
18 years - 100 years
All
Phase
N/A
360 participants needed
1 Location
Brief description of study
What is the purpose of this study?
The purpose of this study is to test the hypothesis that skin sympathetic nerve activity (SKNA) can be used as a biomarker for physiological events including predicting neurological recovery during supportive care for cardiac arrest, and to risk stratify patients for recurrence of atrial fibrillation (AF) following catheter ablation.
THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential research subjects will be recruited from the intensive care unit at IU Health Methodist Hospital or from the outpatient cardiology clinic at the Krannert Institute of Cardiology.
Detailed description of study
What will happen during the study?
Skin sympathetic nerve activity (SKNA) recordings will be obtained from ECG electrodes placed on the skin. Recordings will be obtained from patients who are either undergoing supportive care for cardiac arrest (A); or receiving catheter ablation therapy for AF (B). The recordings are obtained non-invasively during routine care in a prospective study. Patients will not be assigned to any intervention.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Cardiac arrest, Atrial fibrilation
-
Age: 18 years - 100 years
-
Gender: All
Primary Outcome A Eligibility
Inclusion criteria:
- Men and women older than 18 years of age
- Undergo supportive care for cardiac arrest as part of the patients’ routine care
Exclusion criteria:
- Pacemaker dependent
- Pacing artifacts prevents SKNA analyses
- Allergic to skin patch electrodes
- Current employees, student or trainee of Krannert Cardiovascular Research Center
- Vulnerable population
Primary Outcome B Eligibility
Inclusion criteria:
- Men and women older than 18 years of age
- Come to the outpatient clinic and have blood drawn as part of routine care.
- Undergoes catheter ablation therapy for paroxysmal or persistent atrial fibrillation as part of the patient’s routine care.
Exclusion criteria:
- Active thyrotoxicosis
- Abnormal sympathetic tone
- Pacemaker dependent
- Pacing artifacts prevents SKNA analyses
- Allergic to skin patch electrodes
- Current employees, student or trainee of the Krannert Cardiovascular Research Center
- Vulnerable population
Updated on
25 Feb 2025.
Study ID: KIC-IIR-EVERETT-SKNA-AF-TTM, 13971
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