Whole Blood in Trauma Patients
R
Rachel Rodriguez, MD
Primary Investigator
J
Jeremy Levin, MD
Primary Investigator
Enrolling By Invitation
18-80 years
All
Phase
N/A
200 participants needed
2 Locations
Brief description of study
We seek to determine what ratio mitigates ongoing blood loss and thus transfusion need. Because the need for whole blood transfusion is not common across most trauma centers, we seek to perform a multicenter, prospective, observational study in order to enroll a sufficient number of patients to answer this question in a reasonably timely fashion.
Primary Aim: To determine if there is a dose-response relationship between number of units of
whole blood given and total transfusion need within the first 2, 4, 6, 12 and 24 hours following onset of
hemorrhage.
Secondary Aim: To determine if there is a relationship between number of units of whole blood given
and need for mechanical ventilation, ICU/hospital length of stay, resolution of acidosis, normalization of
vesicoelastography and conventional coagulation indices, morbidity (as defined below) and death.
whole blood given and total transfusion need within the first 2, 4, 6, 12 and 24 hours following onset of
hemorrhage.
Secondary Aim: To determine if there is a relationship between number of units of whole blood given
and need for mechanical ventilation, ICU/hospital length of stay, resolution of acidosis, normalization of
vesicoelastography and conventional coagulation indices, morbidity (as defined below) and death.
Detailed description of study
Primary Aim: To determine if there is a dose-response relationship between number of units of
whole blood given and total transfusion need within the first 2, 4, 6, 12 and 24 hours following onset of
hemorrhage.
Secondary Aim: To determine if there is a relationship between number of units of whole blood given
and need for mechanical ventilation, ICU/hospital length of stay, resolution of acidosis, normalization of
vesicoelastography and conventional coagulation indices, morbidity (as defined below) and death.whole blood given and total transfusion need within the first 2, 4, 6, 12 and 24 hours following onset of
hemorrhage.
Secondary Aim: To determine if there is a relationship between number of units of whole blood given
and need for mechanical ventilation, ICU/hospital length of stay, resolution of acidosis, normalization of
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Trauma, bleeding
-
Age: Between 18 Years - 80 Years
-
Gender: All
Inclusion Criteria:Age 18-80 years old
Acute injury (any mechanism)
Received blood transfusion via a dedicated massive transfusion protocol on arrival to the
hospital
Received both whole blood and component therapy during their initial resuscitationExclusion Criteria:
- Pregnant Prisoner Moribund/expected to die Dead on arrival Died in the trauma bay Transfer from an outside hospital/facility Known use of anticoagulant within 48 hours of injury Head abbreviated injury score 3 or higher
Updated on
01 Aug 2024.
Study ID: 17220; SURG-IIR-WHOLE-BLOOD
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