Immunoassay of Gingival and Peri-implant Crevicular Fluid
A
Alexandru Movila, PhD
Primary Investigator
Enrolling By Invitation
18-100 years
All
Phase
N/A
104 participants needed
1 Location
Brief description of study
The goal of this study is to use a new immune monitoring (test and define properties of the patient’s cells). This information will help work towards :in vitro panel kit, that analyzes properties like 65 cytokines, chemokines, growth factors/regulators, and soluble receptors simultaneously within
1) the GCF(gingival crevicular fluid) of gender and age matched periodontally healthy and diseased sulci,
2) the PICF (peri-implant crevicular fluid) of gender and aged matched peri implant healthy and periimplantitis sulci, and
3) to analyze associations between biomarkers found in these sulci (space between tooth and gum tissue) and how they relate to age and gender.
Detailed description of study
GCF/PICF samples will be collected from posterior (premolar and molar teeth). In the case of periodontitis or peri-implantitis, two samples will be collected from two different sites with the deepest probing depth, highest CAL and signs of inflammation, along with radiographic confirmation of bone loss. Sites should preferably be on the same tooth/implant, quadrant, or the same side. PerioPaper strip be used to collect GCF and PICF, by placing it in the sulcus and keeping it for 1 minute in all subject groups.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Gingival and Peri-implant Crevicular Fluid biomarkers
-
Age: Between 18 Years - 100 Years
-
Gender: All
Inclusion Criteria:
·
ASA
Class I or II
·
Age
o Young: 18-65 years old
o Aged: >65 years old
·
Healthy
tissue or gingival inflammation sites (control subjects)
o No radiographic bone loss
o PPD ≤ 4 with no BOP
·
Periodontal
conditions (for infected sites)
·
Periodontitis
-
· Uncontrolled DM II (HbA1c >7% or >53mmol/mol) confirmed by medical records.· Periodontal or periimplant therapy in the last 6 months confirmed by subject self-reporting and dental records at Indiana Universirty School of Dentistry· Used antibiotics or anti-inflammatory drugs in the last 6 months confirmed by subject self-reporting.
Updated on
01 Aug 2024.
Study ID: 19010; OHRI-IIR-IMMUNOASSAYS
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