Functional Assessment in Liver Transplantation (FrAILT) Study
M
Marwan Ghabril
Primary Investigator
Enrolling By Invitation
18 years - 100 years
All
Phase
N/A
10 participants needed
1 Location
Brief description of study
What is the purpose of this study?
This will be a prospective cohort study of patients with liver disease. Subjects will undergo geriatric assessments of frailty, functional status, and disability using functional status measures at baseline and at every clinic visit in the pre-transplant setting. Subjects will also answer questions regarding quality of life, personality, and/or cognitive function. Subjects will again undergo assessments at every clinic visit through 12 months after transplant. Then, they will be followed annually.
This will be a prospective cohort study of patients with liver disease. Subjects will undergo geriatric assessments of frailty, functional status, and disability using functional status measures at baseline and at every clinic visit in the pre-transplant setting. Subjects will also answer questions regarding quality of life, personality, and/or cognitive function. Subjects will again undergo assessments at every clinic visit through 12 months after transplant. Then, they will be followed annually.
THIS STUDY IS ENROLLING BY INVITATION ONLY
Detailed description of study
What will happen during the study?
Patients will be asked to perform the following study procedures:
- Assessment of cognitive function, quality of life, and/or personality using cognitive tests and questionnaires.
- Measures of frailty and disability selected to capture the multi-dimensional aspects of frailty including functional status and physiologic reserve:
- Fried Frailty Score: weakness (test of grip strength), exhaustion (patient interview), slowness (gait speed), low activity (patient interview) Short Physical Performance Battery: repeated chair stands, balance testing with feet together, 13-foot walk
- Laboratory tests will all be obtained from the medical record: creatinine, total bilirubin, INR, sodium, albumin. All of these tests are necessary for listing for liver transplantation.
- Blood draw, urine and stool samples will be collected for a sub-group of 1000 patients.
- Adipose, muscle, liver tissue, and blood will be collected during the liver transplant surgery for a sub-group of 1000 patients.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: End Stage Liver Disease
-
Age: 18 years - 100 years
-
Gender: All
Inclusion Criteria:
- Are seen for the treatment of liver disease
Updated on
21 Apr 2025.
Study ID: GI-UCSF-FRAILT, 21968
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