EXAMINING THE ROLE OF ALLOSTATIC LOAD IN RACIAL DISPARITIES IN INTRINSIC BREAST CANCER SUBTYPE AND AS A PROGNOSTIC MARKER

Understanding Stress and Race in Breast Cancer

T
Tarah Ballinger, MD

Primary Investigator

Recruiting
18 years - 100 years
All
Phase N/A
10 participants needed
4 Locations

Brief description of study

The main purpose of this study is to better understand the relationship between stress, race, and breast cancer.
 
Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:
IU Clinical Trials Office 
Phone: (317) 278-5632

Detailed description of study

This study will include a retrospective cohort for the creation of the AL measure and a prospective cohort for the validation of AL.  The patients for the prospective cohort will be recruited from OSUCCC, Indiana University Cancer Centers, and MetroHealth Systems. Further, data from the prospective cohort will be used to examine the relationship between AL, race, intrinsic breast cancer subtype, the tumor microenvironment and tumor mutations.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Breast Cancer
  • Age: 18 years - 100 years
  • Gender: All

Inclusion criteria
•    Newly diagnosed yet untreated self-reported Non-Hispanic Black, Non-Hispanic White, Hispanic-Black, and Hispanic White patients with breast cancer, regardless of performance status ages ≥18 with clinical stages I-III breast cancer at diagnosis
•    Patients should have received one component of treatment (surgery, chemotherapy, or radiation therapy) at OSUCCC
•    No prior cancer diagnosis 
•    Diagnosed between 01/01/2012-12/31/2022
      

Exclusion criteria
•    Incarcerated individuals
•    Men
•    Known personal history of ductal carcinoma in situ (DCIS) or invasive breast cancer
•    Stage IV breast cancer
•    women identifying as American Indian, Alaskan Native, Asian, Native Hawaiian or Other Pacific Islander 
 

This study investigates the connection between stress, race, and breast cancer. Breast cancer is a disease where cells in the breast grow uncontrollably. The study looks at how stress and racial differences may affect breast cancer types and outcomes.

Participants will be part of two groups: one to develop a stress measure and another to test it. The study will collect data from people treated at specific cancer centers to see how stress, race, and breast cancer are related.

  • Who can participate: Adults aged 18 and older with clinical stages I-III breast cancer who have not been treated. Participants must be Non-Hispanic Black, Non-Hispanic White, Hispanic-Black, or Hispanic White and without prior cancer diagnosis.
  • Study details: Participants will be observed to understand the relationship between stress, race, and breast cancer. No investigational treatments will be administered.
Updated on 23 Sep 2025. Study ID: CTO-2023C0120, 22506

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