Investigation of Intracranial Pressure Dynamics in Glaucoma: An Innovative Approach
T
Tasneem Putiwala Sharma
Primary Investigator
Enrolling By Invitation
18 years - 100 years
All
Phase
N/A
30 participants needed
1 Location
Brief description of study
What is the purpose of this study?
We propose using optic ultrasonography to measure optic nerve sheath diameter, as an indicator of intracranial pressure, within the glaucoma population at the Ophthalmology health clinics at Indiana University School of Medicine (Eugene and Marilyn Glick Eye Institute and Spring Mill clinic) to determine if low intracranial pressure plays a role in glaucoma patients, especially low tension glaucoma. If this study determines that using optic nerve sheath diameter in place of lumbar punctures is a reliable method to measure intracranial pressure, and that low intracranial pressure is involved in glaucoma, then this could indicate the possibility of a non-invasive, cost-effective method to evaluate intracranial pressure in glaucoma patients, aiding in earlier diagnosis.
THIS STUDY IS ENROLLING BY INVITATION ONLY - Any patient seen in clinic at Eugene and Marilyn Glick Eye Institute that consents to optic ultrasonography and fits the inclusion criteria may be eligible and invited to participate.
Detailed description of study
What will happen during the study?
- During the clinic visit, participants will have an ultrasound done to each eye as part of the study.
- The procedure will be about 5-10 minutes long and rarely can have a minimal event such as eye irritation. Both eyes will undergo the procedure. Ultrasonography is a safe, non-invasive procedure with no limits to activity after the procedure.
- This study only requires one visit, which can be done at the normal clinic appointment.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Glaucoma
-
Age: 18 years - 100 years
-
Gender: All
Inclusion Criteria
• Any POAG patients of the Eugene and Marilyn Glick Eye Institute willing to consent to optic ultrasound via written IRB consent.
o This includes LTG patients.
o This includes patients with history of lumbar puncture for objective 2.2.1
Exclusion Criteria
• Any patients of the Eugene and Marilyn Glick Eye Institute with optic nerve abnormalities other than glaucoma.
• Any patients of the Eugene and Marilyn Glick Eye Institute with severe retinal disease that might impact the RNFL such as S/P Pan-retinal laser.
• Any patients of the Eugene and Marilyn Glick Eye Institute with inherited retinal dystrophies like Retinitis Pigmentosa.
• Any patients of the Eugene and Marilyn Glick Eye Institute with history of disc edema.
• Any POAG patients of the Eugene and Marilyn Glick Eye Institute willing to consent to optic ultrasound via written IRB consent.
o This includes LTG patients.
o This includes patients with history of lumbar puncture for objective 2.2.1
Exclusion Criteria
• Any patients of the Eugene and Marilyn Glick Eye Institute with optic nerve abnormalities other than glaucoma.
• Any patients of the Eugene and Marilyn Glick Eye Institute with severe retinal disease that might impact the RNFL such as S/P Pan-retinal laser.
• Any patients of the Eugene and Marilyn Glick Eye Institute with inherited retinal dystrophies like Retinitis Pigmentosa.
• Any patients of the Eugene and Marilyn Glick Eye Institute with history of disc edema.
Updated on
20 Mar 2025.
Study ID: OPTH-IIR-ICP, 21316
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