Examining Genetic Ancestry, Allostatic Load and Treatment Completion among Patients with Breast Cancer

Investigating Treatment Completion in Breast Cancer Patients

T
Tarah Ballinger, MD

Primary Investigator

Recruiting
18 years - 100 years
Female
Phase N/A
3 participants needed
4 Locations

Brief description of study

The main purpose of this study is to learn more about how genetic ancestry affects treatment completion for patients who are diagnosed with breast cancer. 
 
Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:
IU Clinical Trials Office 
Phone: (317) 278-5632

Detailed description of study

 
  • This study is a multi-institutional prospective observational cohort study of newly diagnosed self-reported Black and White women with stages I-III breast cancer patients aged ≥18. 
  • At study entry, baseline information on sociodemographic factors, clinical factors, AL biomarkers and patient reported outcomes will be collected.
  • Patients will complete required surveys and will be recruited over a 3-year period at OSUCCC, IU Health and MetroHealth.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Breast Cancer
  • Age: 18 years - 100 years
  • Gender: Female

Inclusion Criteria:
  • Newly diagnosed yet untreated self-reported Non-Hispanic Black, Non-Hispanic White, Hispanic-Black, and Hispanic White patients with breast cancer, regardless of performance status ages ≥18 with clinical stages I-III breast cancer at diagnosis
  • Scheduled to receive chemotherapy and/or radiation therapy at any of the OSUCCC, IU Health or MetroHealth System locations
  • Patient can provide written informed consent
  • Fluent in English (for completion of study measures)
  • No prior cancer diagnosis or systemic therapy or radiation therapy.
Exclusion Criteria:
  • Incarcerated individuals
  • Men
  • Individuals not able to speak and understand English
  • Known personal history of ductal carcinoma in situ (DCIS) or invasive breast cancer
  • Stage IV breast cancer
  • Women identifying as American Indian, Alaskan Native, Asian, Native Hawaiian or Other Pacific Islander will be excluded

This study investigates how genetic ancestry affects the completion of treatment in patients diagnosed with breast cancer. Breast cancer is a disease where cells in the breast grow out of control. This study involves newly diagnosed women with stages I-III breast cancer who self-report as Black or White.

Participants will provide baseline information about their background and health, including biomarkers and personal reports. They will also complete surveys. This is an observational study, meaning researchers will collect information without changing participants' treatments.

  • Who can participate: Adults aged 18 and older who are newly diagnosed with stages I-III breast cancer and identify as Non-Hispanic Black, Non-Hispanic White, Hispanic-Black, or Hispanic White can participate. Participants must be scheduled to receive chemotherapy or radiation therapy and be fluent in English.
  • Study details: Participants will fill out surveys and provide information about their health and background. The study will observe participants over time to understand the effects of genetic ancestry on treatment completion.
Updated on 23 Sep 2025. Study ID: CTO-2022C0174, 18805

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