Breath-based Diagnosis of Pulmonary Exacerbations in Children with Cystic Fibrosis
M
Mangilal Agarwal
Primary Investigator
Enrolling By Invitation
5 years - 15 years
All
Phase
N/A
100 participants needed
1 Location
Brief description of study
What is the purpose of this study?
The purpose of this study is to obtain and measure compounds found in exhaled breath samples collected from children with Cystic Fibrosis (CF). These compounds should be different when CF patients are healthy compared to when they have an exacerbation. This information could help the study team develop a non-invasive way to monitor exacerbations in people with CF in the future.
THIS STUDY IS ENROLLING BY INVITATION ONLY - Parents and guardians of children with Cystic Fibrosis (CF) who have been hospitalized at Riley Hospital for Children will be identified and approached by the research team about study participation.
Detailed description of study
What will happen during the study?
- Patients will donate breath samples using two different methods.The first method will collect breath samples tidally through a viral filter into a 3 L Tedlar bag (~ 2.5 L of breath in < 1 minute)
- The second method will collect ~ 0.5 L of breath onto adsorption tubes using the ReCIVA device commercially available by Owlstone Medical.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Cystic Fibrosis, CF
-
Age: 5 years - 15 years
-
Gender: All
Inclusion Criteria
• Children with CF followed at Riley Hospital for Children
• 8-18 years of age
• Able to perform standard pulmonary function testing (FEV1pp readings)
• Hospitalized at Riley Hospital for Children for IV antibiotics to treat a PEx
• Able to provide consent/assent as applicable
Exclusion Criteria
• Respiratory culture positive for non-tuberculous mycobacteria within the last 24 months
• Any history of solid organ transplantation
• Children with CF followed at Riley Hospital for Children
• 8-18 years of age
• Able to perform standard pulmonary function testing (FEV1pp readings)
• Hospitalized at Riley Hospital for Children for IV antibiotics to treat a PEx
• Able to provide consent/assent as applicable
Exclusion Criteria
• Respiratory culture positive for non-tuberculous mycobacteria within the last 24 months
• Any history of solid organ transplantation
Updated on
05 Apr 2025.
Study ID: INFO-IIR-BREATH-CF, 23179
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