Inclusion Criteria:

•     Subject is at least 22 years of age on the date of informed consent
•   Subject can provide informed consent
•   Subject requires a surgical procedure for 1 of the 4 specialty treatment groups (ie, lower extremity orthopedic procedure, abdominal or C-section procedure, sternotomy, or vascular procedure)
•   Subject is willing and able to return for all scheduled study visits.
•   Subject has 1 or more of the following risk factors for post-surgical complications:
•       BMI ≥ 30
•       diabetes
•       history of smoking
•       immune suppression or receiving drugs that can cause immune suppression (eg, steroids, chemotherapeutic medications, and/or antimetabolites)
•       high risk for malnutrition, as indicated by 2 or more of the following1:
•           insufficient energy intake
•           loss of muscle mass
•           loss of subcutaneous fat
•           localized or generalized fluid accumulation that may mask weight loss
•           diminished functional status as measured by hand-grip strength
•   OR -
•       has malnutrition, as determined by the investigator
•           neutropenia
•           cardiac, pulmonary, liver, or renal disease
•           history of previous surgery or radiation in the treatment area
•   Subject is pre-operatively assessed to undergo a procedure with a CDC Wound Classification of:
•       Class I (Clean): An uninfected operative wound in which no inflammation is encountered, and the respiratory, alimentary, genital, or uninfected urinary tract is not entered
•   OR -
•       Class II (Clean Contaminated): An operative wound in which the respiratory, alimentary, genital, or uninfected urinary tract are entered under controlled conditions and without unusual contamination
•   Subject has a closed post-surgical incision for which the anticipated duration of Prevena Therapy is more than 11 days

Exclusion Criteria:

•     Subject is female and, except in the case of C-section procedures, is pregnant or lactating prior to surgery
•   Subject has signs of an infection in the surgical area or has signs of a systemic infection at the time of surgery
•   Subject is a chronic opioid user, defined per the CDC guidelines as opioid use for > 3 months, at the time of enrollment
•   Subject has any of the following:
•       condition(s) that, in the opinion of the investigator, cause the patient to be an overall health risk that is unsuitable for the surgery
•       known sensitivity to the study product components (drape and/or dressing materials in direct contact with the closed incision or skin)
•       known sensitivity to silver
•       skin cancer localized at or in proximity to the incision site
•       intraoperative issue(s) that precludes the use of Prevena Therapy
•   Subject is preoperatively assessed to undergo a procedure with a CDC Wound Classification of:
•       Class III (Contaminated): Open, fresh, accidental wounds, and/or major breaks in sterile technique or gross spillage from the gastrointestinal tract
•   OR -
•       Class IV (Dirty-Infected): Old traumatic wounds with retained devitalized tissue and those that involve existing clinical infection or perforated viscera
•   Subject is enrolled in another interventional clinical study