Outcomes of Stent Placement in Adults with Idiopathic Intracranial Hypertension and Venous Sinus Stenosis

Study on Stent Placement for Adults with Pressure Inside the Skull

Primary Investigator
B
Bradley N. Bohnstedt, MD

Primary Investigator

Enrolling By Invitation
18 years - 100 years
All
Phase N/A
10 participants needed
2 Locations

Brief description of study

Venous sinus stenosis has been identified as a potential etiology in Adults with Idiopathic Intracranial Hypertension (IIH). IIH can lead to significant disability including loss of vision, disabling headaches, and neurocognitive impairment. This study will analyze outcome data of stenting in adult patients with IIH and venous sinus stenosis. 
 
THIS STUDY IS ENROLLING BY INVITATION ONLY - Participants will be evaluated in clinic or in the emergency department. Determination of intervention will be made by primary surgeon in accordance to standard of care. Patients will be asked to participate in the study if they meet our inclusion criteria.

Detailed description of study

Study tasks:
  • A baseline quality of life survey, which includes the IIH quality of life survey and HIT-6 survey, will be administered before operation.
  • Duration of quality of life surveys will take approximately 10 minutes.
  • During the procedure, patients will have two pressure recordings at the venous sinus stenosis. This will be done by using a fiberoptic wire and an arterial line attached to the catheter before and after stent placement.
  • There is no additional risk, as the arterial line setup will be attached to the catheter and wire already being used for the stent placement.
  • As part of routine clinical care, patients follow up in 1 month, 6months, and 1 year with their provider.
  • During routine clinical follow up, we will administer another quality of life survey at 1 month, 6 months, and 1 year.
  • Patients will additionally have blood drawn for analysis at the 6 month follow up appointment. This will be done for all patients that consent to be included in the trial and is not standard of care, unless otherwise indicated. These blood draws will be done by trained staff and take no more time than a standard blood draw for a CBC.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Idiopathic intracranial hypertension, Venous sinus stenosis
  • Age: 18 years - 100 years
  • Gender: All

Inclusion criteria: 

  • Patients diagnosed with IIH displaying symptoms refractory tomedication treatment
  • Venous imaging shows venous sinus stenosis

This study investigates the outcomes of stent placement in adults who have Idiopathic Intracranial Hypertension (IIH) with venous sinus stenosis. IIH is a condition that can cause severe headaches, vision problems, and thinking difficulties. Venous sinus stenosis refers to a narrowing of the veins in the brain, which may contribute to these symptoms.

In this study, participants will complete surveys about their quality of life before and after the stent procedure. During the procedure, doctors will measure pressure in the narrowed veins. Follow-up visits will include more surveys and a blood test at six months to check on participants' health.

  • Who can participate: Adults with IIH whose symptoms do not improve with medication can participate. They must also have a narrowing in their brain veins.
  • Study details: Participants will complete quality of life surveys and have pressure measured during their stent procedure. They will have follow-up visits with more surveys and a blood test at six months.
  • Study timelines and visits: The study will last 1 year. The study requires 4 visits.
Updated on 18 Aug 2026. Study ID: 22536
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Interested in the study?

This study is accepting only persons who receive care at a certain clinic or doctor or who are part of an invited group. Questions about this study can be directed to the study team listed in the description or contact your doctor to see if you are eligible.

Accepting Referrals by Invitation Only