Genetics and Local Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome
Studying Genes in Muscle Pressure Condition
Dillon O'Neill
Primary Investigator
Brief description of study
The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower extremity fractures who do not develop compartment syndrome. We are participating in a portion of the larger University of Utah study to increase enrollment numbers. We have included the University of Utah study protocol for an overview of the larger study. IU site is exclusively involved in the Acute Injury Group, which specifically includes patients diagnosed with acute compartment syndrome.
Detailed description of study
A tissue sample will be collected from the tissue discarded during the standard of care surgery to address compartment syndrome.
In addition to that, 10mL blood sample will be collected, which is not part of SOC and is for research purpose only.
If the patient needs any additional surgeries, another discarded initial debridement tissue sample and blood sample will be taken.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Acute Compartment Syndrome
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Age: 18 years - 100 years
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Gender: All
Inclusion Criteria
- Patient 18+ years of age.
- Patients with the clinical diagnosis of lower leg acute compartment syndrome secondary to tibial shaft or tibial plateau fracture or exertional compartment syndrome with planned surgical intervention.
The purpose of this study is to investigate the genetic differences and local gene expression in people who develop acute traumatic compartment syndrome. Compartment syndrome is a serious condition where increased pressure within a muscle compartment reduces blood flow, affecting tissue health. This study compares individuals with compartment syndrome to those with similar injuries who do not develop the condition.
Participants will have a tissue sample collected during their standard care surgery for compartment syndrome. Additionally, a small blood sample will be taken for research purposes. If more surgeries are needed, further tissue and blood samples will be collected.
- Who can participate: Adults aged 18 and older with a diagnosis of lower leg acute compartment syndrome related to specific types of fractures or exertional compartment syndrome are eligible.
- Study details: Participants will provide tissue samples from their surgery and blood samples for research.
