Personality traits and induced laryngeal obstruction

R
Robert Fujiki

Primary Investigator

Enrolling By Invitation
8 years - 80 years
All
Phase N/A
50 participants needed
4 Locations

Brief description of study

What is the purpose of this study?

Paradoxical Vocal Fold Movement (PVFM; also called Induced Laryngeal Obstruction [ILO]) consists of vocal fold adduction which occurs upon inspiration and results in dyspnea. The etiology of PVFM is often multifactorial and varied across patients. PVFM has been categorized in the literature based on supposed triggers, with subtypes including irritant-induced, exercise induced and that associated with psychogenic causes. Although the etiology of PVFM is not believed to be exclusively psychological in nature, it has been reported to be associated with anxiety and/or depression.  This study aims to clarify personality types which place individuals at risk for induced laryngeal obstruction. We will also consider the mood states prevalent in this population.

THIS STUDY IS ENROLLING BY INVITATION ONLY -   Potential participants who are patients at the Voice and Swallow Clinics will be identified and contacted by teh study team. Speech-Language Pathologist (SLP) laryngologist, or a study team member will screen patients seen at the Voice and Swallow Clinic who are within the appropriate age range by reviewing their medical chart to determine if the patient meets initial eligibility requirements. If the patient is a potential candidate, the SLP, physician, or nurse who the patient recognizes as being involved in their care will approach the patient about the study at their scheduled appointment. If the study was not presented to the potential participant at the time of their scheduled standard of care appointment, the patient may bed telephoned to see if they would like to participate in the study.

Detailed description of study

What will happen during the study?

Participation will involve completing an online survey that will take between 10 and 15 minutes - either with the clinician present or at home at their leisure. This will be the participant's choice. Patients will either be emailed a survey link in REDCap or presented with a REDCap QR code. Surveys may also be completed in clinic through a REDCap link on an iPad or phone (accessed via QR code).

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Healthy, Paradoxical Vocal Fold Movement, PVFM, Induced Laryngeal Obstruction, ILO, Dyspnea
  • Age: 8 years - 80 years
  • Gender: All

Inclusion Criteria
Patient Group -Age between 8 and 80 years of age -Read and write English -Patients must be diagnosed with or have a suspected diagnosis of PVFM. As is customary, diagnosis will be determined by the physician or SLP based on nasal endoscopy (routinely performed in clinic). Patients diagnosed with PVFM based on with laryngeal adduction (complete or partial) upon inhalation will be eligible for inclusion in this study. If physician’s suspected diagnosis is PVFM and laryngeal adduction upon inhalation is not observed on exam, following standard of care, patients may still be included if they present with dyspnea upon inhalation and meet one of the following criteria... i. Inspiratory inhalation occurs with physical exercise or athletics ii. Dyspnea resolves quickly after cessation of physical activity iii. Dyspnea is localized to the level of the larynx iv. Poor response to inhalers or steroids v. Truncation of the inspiratory component of the flow-volume loop vi. Poor or no response to bronchodilators vii. Negative or inconsistent bronchoprovocation results viii. Normal chest x-ray or oxygen saturation ix. Inhalatory stridor x. Dyspnea is triggered by specific scents, irritants, or environments Control Group -Age between 8 and 80 years of age -Read and write English -No history of PVFM

 

Exclusion Criteria

-Diagnosed with a respiratory disease other than asthma (asthma is okay) -Current diagnosis of head or neck cancer, or terminal illness -Cancer, terminal diagnoses, or neurological conditions resulting in impaired cognition.

Updated on 07 May 2025. Study ID: OTHN-IIR-26458, 26458
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