Adaptation in the forearm bones of tennis players assessed using novel approaches
Stuart Warden
Primary Investigator
Brief description of study
What is the purpose of this study?
We are seeking adult males to participate in a study exploring the benefits of exercise on the human skeleton. and bone health.
Detailed description of study
What will happen during the study?
There will be two groups of participants--tennis players and controls. The study involves attending IU Health University Hospital on the Indiana University Indianapolis campus for a 3-hour visit where will assess the bones in your forearms.
During the visit, we will ask you to:
1. Complete two short questionnaires
2. Lie still for up to 20 minutes at a time while we take of images your forearm bones using a magnetic resonance imaging (MRI) scanner
3. Participate in another study called the Function, Imaging and Testing study where we will be asked to:
a. Lie still for up to 3 minutes at a time while we take of images your arm bones using two different imaging machines
b. Lie still for up to 10 minutes on a machine while a small force (up to 2 lbs) is applied to your forearm bones to measure their stiffness
c. Perform physical tests, such as walking as far as you can in 6 minutes, standing up from a chair as many times as you can in 30-s, and squeezing a force sensing device as hard as you can with your hand.
d. Provide a blood sample
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Healthy
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Age: 18 years - 24 years
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Gender: Male
Inclusion Criteria
Tennis players will be included if they:
a) Are male and aged 18-24 years
b) Have been playing tennis for at least 10 years
c) Currently play tennis on a collegiate-level team
d) Concurrently enroll in the FIT Core protocol (IRB #1707550855)
Control individuals will be included if they:
a) Are male and aged 18-24 years
b) Do not have a history of participating more than 2X/month for >6 months in an activity that may preferentially load one arm (e.g., tennis, softball, javelin, table tennis, hammer toss, discus, etc.).
c) Concurrently enroll in the FIT Core protocol (IRB #1707550855; please refer to the separate protocol for further details related to specific inclusion and exclusion criteria in that protocol)
Exclusion Criteria
a) Any known metabolic bone disease or prior or current administration of any bone-specific pharmacological agent (e.g., anti-resorptive or anabolic therapy)
b) History of a forearm (radius or ulna) or wrist fracture in the past 5 years
c) Surgery and/or immobilization for more than 2 weeks on either arm in the past 2 years
d) Implanted metal (e.g., orthopedic hardware) at any of the imaging sites
e) Contraindications for MRI
f) Ineligible to enroll in the FIT Core protocol (IRB #1707550855; please refer to the separate protocol for further details related to specific inclusion and exclusion criteria in that protocol)
