Innovative Cognitive Impairment Case Finding And Engagement For Diverse Participation In Alzheimer's Disease Care, Treatment, And Research
Investigating Cognitive Impairment Detection in Alzheimer's Disease
Nicole Fowler
Primary Investigator
Brief description of study
This project aims to test the acceptability and feasibility of implementing Passive Digital Marker (PDM) in IUH PC to identify people with and at risk of MCI and ADRD using EMR data. For this study, patients who screen positive using the PDM will be contacted through IU Health’s patient messaging platform, Twistle. They will be encouraged to discuss their brain health with their PCP at their upcoming appointment, and engage in follow-up care with a Brain Health Navigator.
THIS STUDY IS ENROLLING BY INVITATION ONLY - Patients identified by the PDM will be contacted using a secure Twistle message. The PDM is a machine learning algorithm that will be used to identify patients at risk for cognitive decline based on their health information. All eligible patients identified as PDM+ will be contacted via twistle message once their next primary care appointment is scheduled. All patients will be offered to establish care with the Brain Health Navigator, and patients' providers will be notified of the PDM status.. Patient care will be provided at IU Health primary care clinics which have established measures for safeguarding individual medical and personal information in acoordance with HIPAA regulations. accordance
Detailed description of study
Aim 1: To implement the PDM, using IUH EHR data, to identify primary care patients aged 65 and older who a have uniagnosed MCI or ADRD or who are at risk (1b) of developing ADRD .
Aim 2: Design a patient-informed messaging strategy to enhance engagement among PC patients identified with a positive PDM, in two critical areas: (2a) cognitive assessments and (2b) participation in clinical research.
Aim 3: Evaluate the effectiveness of the patient-informed messaging strategy delivered through IUH s patient facing application, Twistle, in engaging PDM-positive patients to complete a (3a) cognitive assessment with the BHN (primary outcome) and engage in (3b) clinical research by signing up for the ICTSI ALL IN registry and/or the IU Biobank (secondary outcomes).
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Healthy, Dementia, Alzheimer’s Disease, Mild Cognitive Impairment, MCI, ADRD
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Age: 65 years - 100 years
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Gender: All
Inclusion Criteria
Aims 1: Patients aged 65 years and older who are established at one of the 10 selected IU Health PC clinics and have a scheduled PC visit within the next 30 days
Aim 2: 65 years and older and an established patient of any IUH PC clinic; care partner of an IUH patient with MCI or ADRD; able to give informed consent to participat in research jam.
Aims 3: 65 years and older; established patients of 10 selected clinics at IU Health PC who are identified by the PDM as high risk for developing or having undetected MCI or ADRD.
Exclusion Criteria
Aims 1 and 3: Patients younger than 65 years; new patients to IUH (less than 12 months); individuals whose primary language is neither English nor Spanish; and current diagnosis of ADRD or MCI.
Aim 2: Inability to give informed consent and individuals whose primary language is not English
This study investigates the use of a Passive Digital Marker (PDM) to identify people at risk of Mild Cognitive Impairment (MCI) and Alzheimer's Disease and Related Dementias (ADRD). The PDM is a tool that uses electronic medical records to find patients who might be at risk. Patients identified by the PDM will be contacted through a secure messaging platform to discuss their brain health with their primary care provider.
Participants will receive messages encouraging them to engage in follow-up care with a Brain Health Navigator. The study will also design and test messaging strategies to help patients complete cognitive assessments and participate in clinical research. The messaging is delivered through a patient-facing application to enhance engagement and participation.
- Who can participate: Participants must be 65 years or older, established patients at selected IU Health primary care clinics, and have a scheduled primary care visit within the next 30 days. They must be identified by the PDM as at risk and able to give informed consent.
- Study details: Participants will be contacted through a secure messaging platform to discuss brain health with their primary care provider. They will also be invited to follow-up care with a Brain Health Navigator and participate in clinical research.
