Chronic Headache due to Mild Traumatic Brain Injury in Adults: Alterations of Brain Function Central Sensitization and Inflammatory Processes

Overview

The purpose of this study is to teach us more about why some people often experience headaches after having a mild traumatic brain injury. We need individuals who have NOT experienced a traumatic brain injury.

Description

The purpose of this study is to teach us more about why some people often experience headaches after having a mild traumatic brain injury. We want to determine whether certain factors place individuals more at risk for experiencing headaches after a mild traumatic brain injury including pain sensitivity, how the body adapts to pain, levels of inflammation in our blood, and changes in brain structure and function.

Eligibility

You may be eligible for this study if you meet the following criteria:

  • Conditions: headache,healthy,mild traumatic brain injury
  • Age: Between 18 Years - 65 Years
  • Gender: Male or Female

Inclusion Criteria
In good health
Have not had a traumatic brain injury
Do not experience chronic headaches
Exclusion Criteria
Chronic cardiovascular disease, metabolic disease, or renal disease
Neurological disease (e.g., Parkinson's Disease, multiple sclerosis, epilepsy)
Serious psychiatric conditions (schizophrenia, bipolar disorder) or hospitalization within the preceding year for psychiatric illness
Pre-existing chronic headache defined as having headache > 15 days/month over the past 3 months
Fractures of any kind
Chronic opioid use
Current use of narcotics
Uncontrolled hypertension (or receiving treatment for hypertension with BP of greater than 150/99)
Current involvement in litigation
No metallic foreign bodies in the brain or eye or cardiac pacemakers
Previous traumatic brain injury


Additional Information:
Participants will be compensated for their participation.

Updated on 20 Nov 2022 . Study ID: TX8954

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