Finding Immune Nascent Type 1 Diabetes (Find T1D) Pilot
Investigating Markers of the Immune System's Attack in Type 1 Diabetes
Emily Sims, MD
Primary Investigator
Brief description of study
The purpose of this study is to understand how many individuals who previously participated in the Indiana Biobank will return a home screening kit. The participant will collect a capillary blood sample and hear about the results of testing that sample for markers of autoimmunity linked to type 1 diabetes.
Detailed description of study
Individuals will be asked about interest in a research study related to type 1 diabetes based on prior participation in the Indiana Biobank. Interested individuals will be consented and the participant will be asked if we can use existing testing in Indiana Biobank samples with identifiers to understand if they have genetic markers signaling an increased risk for type 1 diabetes.
The consented individuals will be sent a mail-based home screening kit. Collected samples will be returned to the research team and tested for T1D autoantibodies. Results will be returned to participants and individuals with islet autoantibodies will be provided with the opportunity for follow-up counseling and testing, with referral for clinical follow-up as indicated.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Type I Diabetes genetic risk factor
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Age: 17 years or below
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Gender: All
Inclusion Criteria
1) Participant must have previously participated in Indiana Biobank
2) Participant must be able to provide consent
Exclusion Criteria
1) Refusal to sign informed consent
2) Prior diabetes diagnosis
The purpose of this study is to understand how many individuals who previously participated in the Indiana Biobank will return a home screening kit. Type 1 diabetes is a chronic disease where the body's defense system mistakenly attacks specific cells within the pancreas, which make insulin. Insulin helps control sugar in the blood. When these cells are damaged, they cannot make enough insulin. This means people with Type 1 diabetes need to take insulin every day to keep their blood sugar at safe levels.
Participants will receive a home screening kit to collect a capillary blood sample. This sample will be tested for markers of autoimmunity linked to type 1 diabetes. Results will be shared with participants, and those with islet autoantibodies will have the opportunity for follow-up counseling and additional testing. Referral for clinical follow-up will be provided as needed.
- Who can participate: Individuals who have previously participated in the Indiana Biobank and can provide consent are eligible. Those with a prior diabetes diagnosis or who refuse to sign informed consent are excluded.
- Study details: Participants will collect a capillary blood sample using a home screening kit. The samples will be returned to the research team for testing. Participants will receive their results and may be offered follow-up counseling and testing if autoantibodies are detected.
